Correlations between visual morphological, electrophysiological, and acuity changes in chronic non-arteritic ischemic optic neuropathy

Purpose To study whether there is a correlation between the macular and optic nerve morphological condition and the retinal ganglion cells (RGCs) and visual pathways’ function, and to investigate whether visual acuity (VA) changes might be related to the morpho-functional findings in chronic non-art...

Full description

Saved in:
Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2021-05, Vol.259 (5), p.1297-1308
Main Authors: Barbano, Lucilla, Ziccardi, Lucia, Parisi, Vincenzo
Format: Article
Language:English
Subjects:
Acuity
Axons
Evoked Potentials, Visual
Eye
Humans
Ischemia
Medicine
Medicine & Public Health
Middle Aged
Morphology
Neurophthalmology
Ophthalmology
Optic nerve
Optic neuropathy
Optic Neuropathy, Ischemic - diagnosis
Retina
Retinal Ganglion Cells
Retrospective Studies
Tomography, Optical Coherence
Visual evoked potentials
Visual pathways
Visual perception
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To study whether there is a correlation between the macular and optic nerve morphological condition and the retinal ganglion cells (RGCs) and visual pathways’ function, and to investigate whether visual acuity (VA) changes might be related to the morpho-functional findings in chronic non-arteritic ischemic optic neuropathy (NAION). Methods In this retrospective study, 22 patients (mean age 62.12 ± 6.87) with chronic unilateral NAION providing 22 affected and 22 fellow eyes without NAION (NAION-FE), and 20 (mean age 61.20 ± 7.32) healthy control subjects were studied by spectral domain optical coherence tomography (Sd-OCT) for investigating macular thickness (MT) and volume (MV) of the whole (WR), inner (IR) and outer retina (OR), and the peripapillary retinal nerve fiber layer thickness (RNFL-T) measured overall and for all quadrants. Also, simultaneous 60′ and 15′ pattern electroretinogram (PERG) and visual evoked potentials (VEP) and VA were assessed. Differences of MT and MV of WR, IR, OR, and RNFL-T overall and for all quadrants, PERG amplitude (A), VEP implicit time (IT), and A and VA values between NAION eyes and controls were assessed by one-way analysis of variance. Pearson’s test was used for regression analysis. A p value
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-020-05023-w