Plasma heat shock protein 90 levels in patients with spondyloarthritis and their relation to structural changes: a cross-sectional study

• Published in: Biomarkers in medicine 2021-01, Vol.15 (1), p.5-13
• Main Authors: Bubova, Kristyna, Storkanova, Hana, Oreska, Sabina, Spiritovic, Maja, Hermankova, Barbora, Mintalova, Katerina, Gregova, Monika, Husakova, Marketa, Horinkova, Jana, Forejtova, Sarka, Gatterova, Jindriska, Stolfa, Jiri, Komarc, Martin, Vencovsky, Jiri, Pavelka, Karel, Senolt, Ladislav, Tomcik, Michal
• Format: Article
• Language: English
• Subjects: Adult; Age; Antigens; Arthritis; Arthritis, Psoriatic - blood; Arthritis, Psoriatic - diagnosis; Biomarkers; Biomarkers - blood; Bone marrow; C-reactive protein; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Case-Control Studies; Consortia; Cross-Sectional Studies; Disease; Edema; Female; Gender; Heat shock proteins; HSP90 Heat-Shock Proteins - blood; Hsp90 protein; Humans; Immune response; Inflammation; Inflammatory bowel disease; Inflammatory diseases; Joint diseases; Laboratories; Male; Middle Aged; Nonsteroidal anti-inflammatory drugs; Plasma; Proteins; Psoriatic arthritis; Rheumatic diseases; Rheumatology; Spondylarthritis - blood; Spondylarthritis - diagnostic imaging; Standard deviation; Statistical analysis
• ISSN: 1752-0363; 1752-0371; 1752-0371
• DOI: 10.2217/bmm-2020-0360

Heat shock protein 90 (Hsp90) is a molecular chaperone regulating immune response. We aimed to assess systemic Hsp90 as a biomarker for spondyloarthritis (SpA). Total of 80 axial SpA (axSpA) and 22 psoriatic arthritis patients and a corresponding number of age- and sex-matched healthy controls (HC) were included. Plasma Hsp90 levels were measured by ELISA. Hsp90 was significantly increased in axSpA patients compared with HC (median interquartile range: 15.7 [10.5-19.8] vs 8.3 [6.6-11.8] ng/ml, p