Retinal neurodegeneration, macular circulation and morphology of the foveal avascular zone in diabetic patients: quantitative cross‐sectional study using OCT‐A

Purpose Using OCT‐A to investigate the association between neurodegeneration and vascular morphology in diabetic retinopathy (DR). Methods Cross‐sectional study. One hundred and sixty‐two patients were enrolled and following fundoscopy were assigned to two groups according to DR severity: 54 patient...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2021-11, Vol.99 (7), p.e1135-e1140
Main Authors: Bontzos, Georgios, Kabanarou, Stamatina A., Gkizis, Ilias, Ragkousis, Antonios, Xirou, Tina, Peto, Tunde
Format: Article
Language:English
Subjects:
Capillaries - diagnostic imaging
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetic retinopathy
Diabetic Retinopathy - complications
Diabetic Retinopathy - diagnosis
Female
Fluorescein Angiography - methods
Fovea Centralis - blood supply
Fovea Centralis - diagnostic imaging
Fundus Oculi
Humans
Macular Degeneration - diagnosis
Macular Degeneration - etiology
Male
Middle Aged
Morphology
Neurodegeneration
optical coherence tomography
optical coherence tomography‐angiography
Patients
Retina
Retinal Vessels - diagnostic imaging
Retinopathy
Statistical analysis
Tomography, Optical Coherence - methods
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Summary:Purpose Using OCT‐A to investigate the association between neurodegeneration and vascular morphology in diabetic retinopathy (DR). Methods Cross‐sectional study. One hundred and sixty‐two patients were enrolled and following fundoscopy were assigned to two groups according to DR severity: 54 patients to the group of no clinical signs of DR (noDR) and 54 to the non‐proliferative DR (NPDR) group. Fifty‐four age‐matched patients without known diabetes were recruited as the control group. Patients underwent full ophthalmic examination followed by OCT‐A. Central retinal thickness (CRT), vessel density (VD) in the superficial and deep retinal layers and foveal avascular zone (FAZ) area were measured. Additionally, ganglion cell complex (GCC) layer thickness along with global loss volume (GLV) and focal loss volume (FLV) indices was measured. Results In total, 85 men with mean age of 51.93 ± 9.03 and 77 women with age of 50.14 ± 10.35 were examined. Mean diabetes duration was 4.62 ± 2.16 years in the noDR group and 11.34 ± 2.73 years in the NPDR group (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.14754