ER staining levels affect HER2 staining and heterogeneity

Purpose This study explored the relationship of ER expression levels with HER2 staining properties and heterogeneity and discussed the differences in HER2 assessment caused by the 2018 ASCO/CAP guideline updates from that of the 2013 version. Methods HER2-positive breast cancer was divided into thre...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2021-05, Vol.28 (3), p.720-726
Main Authors: Akashi, Momoko, Yamaguchi, Rin, Kusano, Hironori, Yamaguchi, Miki, Akiba, Jun, Kakuma, Tatsuyuki, Tanaka, Maki, Akagi, Yoshito, Yano, Hirohisa
Format: Article
Language:English
Subjects:
Cancer Research
Medical colleges
Medicine
Medicine & Public Health
Oncology
Original Article
Surgery
Surgical Oncology
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Summary:Purpose This study explored the relationship of ER expression levels with HER2 staining properties and heterogeneity and discussed the differences in HER2 assessment caused by the 2018 ASCO/CAP guideline updates from that of the 2013 version. Methods HER2-positive breast cancer was divided into three groups of the high hormone receptor expression (LH-high) group, low expression (LH-low) group, or negative (NLH) group to (1) compare differences in the percentage of the HER2 IHC test score of 2 + based on the 2013 ASCO/CAP guideline and in the intratumor heterogeneity of HER2 expression for breast cancer with an IHC score of 3 + among these groups, (2) compare the HER2/CEP17 ratio and the average HER2 copy number, and classified ISH groupings according to the 2018 ASCO/CAP guideline algorithm. Results (1) Of 244 HER2-positive breast cancers, the cases with a HER2 IHC score of 2 + ( n  = 54, 22.1%) were significantly more common in the LH-high group ( n  = 45, P  
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-020-01208-7