Tumor Imaging Based on Photon Upconversion of Pt(II) Porphyrin Rhodamine Co-modified NIR Excitable Cellulose Enhanced by Aggregation

We report a bioinspired upconversion (UC) system using a cellulose template, in which an aggregated platinum­(II)-tetraphenylporphyrin (PtTPP) sensitizer is able to excite Rhodamine B as an emitter, enabling near-infrared (NIR)-to-orange wavelength conversions. The comodified cellulose was observed...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2015-12, Vol.1 (12), p.1206-1210
Main Authors: Nagai, Atsushi, Miller, Jason B, Kos, Petra, Elkassih, Sussana, Xiong, Hu, Siegwart, Daniel J
Format: Article
Language:English
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Summary:We report a bioinspired upconversion (UC) system using a cellulose template, in which an aggregated platinum­(II)-tetraphenylporphyrin (PtTPP) sensitizer is able to excite Rhodamine B as an emitter, enabling near-infrared (NIR)-to-orange wavelength conversions. The comodified cellulose was observed to undergo J aggregation of PtTPP in DMSO solution, as indicated by broad, weak absorption bands in the NIR region of the absorption spectrum. Excitation of these NIR J aggregation peaks of PtTPP led to efficient UC emission in the orange wavelength region. These materials were shown to exhibit UC properties in biological settings both in vitro and in vivo, demonstrating utility of UC for tumor imaging.
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.5b00389