Encapsulation and Fluidization Maintains the Viability and Glucose Sensitivity of Beta-Cells

This study presents experimental data of a fluidized-bed bioreactor for the cultivation of encapsulated pancreatic beta-cells. The fluidization quality for the bioreactor was evaluated at different flow rate using bed-expansion parameters. Homogeneous distribution of microcapsules was achieved at a...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2017-08, Vol.3 (8), p.1750-1757
Main Authors: Nikravesh, Niusha, Cox, Sophie C, Ellis, Marianne J, Grover, Liam M
Format: Article
Language:English
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Summary:This study presents experimental data of a fluidized-bed bioreactor for the cultivation of encapsulated pancreatic beta-cells. The fluidization quality for the bioreactor was evaluated at different flow rate using bed-expansion parameters. Homogeneous distribution of microcapsules was achieved at a flow rate of 2000 μL/min. This enabled efficient contact between the encapsulated cells and medium, which contributed to high cell viability. Microcapsule breakage was
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.7b00191