Serum interleukin‐6, interleukin‐17A, and tumor necrosis factor‐alpha in patients with recurrent aphthous stomatitis

Background Recurrent aphthous stomatitis remains the most common disease of the oral mucosa. The aim of this study was to investigate the clinical significance of serum interleukin‐6, interleukin‐17A, and tumor necrosis factor‐alpha in recurrent aphthous stomatitis. Methods Using flow cytometry anal...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2021-04, Vol.50 (4), p.418-423
Main Authors: Shen, Chenlu, Ye, Weijia, Gong, Lijun, Lv, Kejia, Gao, Bicong, Yao, Hua
Format: Article
Language:English
Subjects:
Aphthous stomatitis
Cytokines
Flow cytometry
Humans
Interferon
Interleukin-17
Interleukin-2
Interleukin-6
interleukin‐17A
Mucosa
Necrosis
Recurrence
recurrent aphthous stomatitis
serum
Statistical analysis
Stomatitis
Stomatitis, Aphthous
Tumor necrosis factor
Tumor Necrosis Factor-alpha
Tumor necrosis factor-TNF
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Summary:Background Recurrent aphthous stomatitis remains the most common disease of the oral mucosa. The aim of this study was to investigate the clinical significance of serum interleukin‐6, interleukin‐17A, and tumor necrosis factor‐alpha in recurrent aphthous stomatitis. Methods Using flow cytometry analysis, we detect the level of serum interleukin‐2, interleukin‐6, interleukin‐17A, tumor necrosis factor‐alpha, and interferon‐gamma in 127 patients with recurrent aphthous stomatitis and 20 healthy control cases; compare; and analyze the correlation of each index. Results The levels of serum interleukin‐2, interleukin‐6, tumor necrosis factor‐alpha, and interferon‐gamma in the recurrent aphthous stomatitis group were higher than in the control group, and the differences were statistically significant (P 
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.13158