Biodegradable Charge‐Transfer Complexes for Glutathione Depletion Induced Ferroptosis and NIR‐II Photoacoustic Imaging Guided Cancer Photothermal Therapy

Suffering from the laborious synthesis and undesirable tumor microenvironment response, the exploitation of novel NIR‐II absorbing organic photothermal agents is of importance to promote phototherapeutic efficacy. Herein, two kinds of charge‐transfer complex nanoparticles (TMB‐F4TCNQ and TMB‐TCNQ) a...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2021-04, Vol.60 (15), p.8157-8163
Main Authors: Ou, Changjin, Na, Weidan, Ge, Wei, Huang, Han, Gao, Fan, Zhong, Liping, Zhao, Yongxiang, Dong, Xiaochen
Format: Article
Language:English
Subjects:
Absorption
Biodegradability
Biodegradation
Biosynthesis
Charge transfer
Contrast agents
Depletion
Energy gap
Exploitation
Ferroptosis
Glutathione
Mass extinctions
Nanoparticles
photothermal therapy
supramolecular chemistry
Tumor microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Suffering from the laborious synthesis and undesirable tumor microenvironment response, the exploitation of novel NIR‐II absorbing organic photothermal agents is of importance to promote phototherapeutic efficacy. Herein, two kinds of charge‐transfer complex nanoparticles (TMB‐F4TCNQ and TMB‐TCNQ) are prepared by supramolecular assembly. Because of the larger energy gap between donor and acceptor, TMB‐F4TCNQ presents higher charge‐transfer degree (72 %) than that of TMB‐TCNQ (48 %) in nanoaggregates. Therefore, TMB‐F4TCNQ exhibits stronger NIR‐II absorption ability with a mass extinction coefficient of 15.4 Lg−1 cm−1 at 1300 nm and excellent photothermal effect. Impressively, the specific cysteine response can make the TMB‐F4TCNQ effectively inhibit the intracellular biosynthesis of GSH, leading to redox dsyhomeostasis and ROS‐mediated ferroptosis. TMB‐F4TCNQ can serve as a contrast agent for NIR‐II photoacoustic imaging to guide precise and efficient photothermal therapy in vivo. Cysteine‐responsive charge‐transfer complex nanoparticles (TMB‐F4TCNQ and TMB‐TCNQ) are prepared by supramolecular assembly. The nanoparticles not only extend absorption to the NIR‐II region with high PCE of over 42 %, but also inhibit the intracellular biosynthesis of GSH and induce ferroptosis. TMB‐F4TCNQ is further used for NIR‐II photoacoustic imaging guided ferroptosis and photothermal therapy.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202014852