Carbon-Based Nanobiohybrid Thin Film for Amperometric Glucose Sensing

This pioneering study involved the fabrication of a new class of nanohybrid-based electrochemical glucose biosensor. First, three-dimensional (3D) graphene was fabricated as a platform of multiwalled carbon nanotube (MWCNT). Then, it was used to immobilize glucose oxidase (GOD) on nanohybrid thin fi...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2017-09, Vol.3 (9), p.2059-2063
Main Authors: Bagheri, Samira, Termehyousefi, Amin, Mansouri, Negar, Amani Babadi, Arman, Abd Karim, Mohd Sayuti, Adib Kadri, Nahrizul
Format: Article
Language:English
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Summary:This pioneering study involved the fabrication of a new class of nanohybrid-based electrochemical glucose biosensor. First, three-dimensional (3D) graphene was fabricated as a platform of multiwalled carbon nanotube (MWCNT). Then, it was used to immobilize glucose oxidase (GOD) on nanohybrid thin film via the entrapment technique. The modified glucose biosensor indicated excellent biocatalytic activity toward the glucose measurment with a sensitivity of up to 49.58 μA mM–1 cm–2 and a wide linear dynamic range up to 16 mM. The fabricated biosensor shows an excellent stability of 87.8%, with its current diminishing after 3 months. This facile and simple electrochemical method for glucose monitoring using a modified glassy carbon electrode (GCE) by 3DG-MWCNT-GOD could open new avenues in producing of a inexpensive and sensitive glucose nanobiosensors.
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.7b00325