Echocardiographic evaluation of pulmonary hypertension, right ventricular function, and right ventricular-pulmonary arterial coupling in patients with rheumatoid arthritis

• Published in: Clinical rheumatology 2021-07, Vol.40 (7), p.2651-2656
• Main Authors: Azpiri-Lopez, Jose R., Galarza-Delgado, Dionicio A., Colunga-Pedraza, Iris J., Arvizu-Rivera, Rosa I., Cardenas-de la Garza, Jesus A., Vera-Pineda, Raymundo, Davila-Jimenez, Jose A., Martinez-Flores, Carolina M., Rodriguez-Romero, Alejandra B., Guajardo-Jauregui, Natalia
• Format: Article
• Language: English
• Subjects: Blood pressure; Cardiovascular diseases; Congestive heart failure; Coronary artery disease; Echocardiography; Hypertension; Medicine; Medicine & Public Health; Original Article; Patients; Pulmonary arteries; Pulmonary artery; Pulmonary hypertension; Rheumatoid arthritis; Rheumatology; Ventricle
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-020-05544-z

Introduction Rheumatoid arthritis (RA) patients are at increased risk for developing cardiovascular disease, including right heart failure. The evaluation of right ventricle (RV) using the relationship between tricuspid annular plane systolic excursion (TAPSE) and right ventricular systolic pressure (RVSP) is of clinical prognostic relevance. Mild echocardiographic pulmonary hypertension (ePH) has been associated with worse RV function. The aim of this study was to evaluate RV function as measured by TAPSE to RVSP ratio in rheumatoid arthritis patients compared to matched healthy controls. Method A case-control study with 67 RA patients aged 40 to 75 years that fulfilled the 2010 ACR/EULAR criteria and 45 matching controls was included. A transthoracic echocardiogram was performed to all patients. TAPSE was measured as the distance traveled from end-diastole to end-systole. RVSP was calculated using the modified Bernoulli equation. Comparisons were done using Chi-square and Mann-Whitney’s U test or Student’s t test. Results Patients with RA had significantly reduced ventricular function (TAPSE 23 [21-25] vs 25 [23-26], p = 0.033) and TAPSE/RVSP ratio was significantly lower in RA-patients than controls (TAPSE to RVSP ratio 0.809 [0.67-1.01] vs 0.933 [0.79-1.11], p = 0.009). RA-patients with mild ePH had similar RV function, evaluated by TAPSE, in comparison to RA-patients with normal RVSP. Conclusion RA-patients had worse RV function measured by TAPSE and worse TAPSE/RVSP ratio than controls. Also, RA-patients with mild ePH had reduced right ventricular-pulmonary arterial coupling in comparison with patients with RA and normal RVSP. These echocardiographic findings could justify aggressive treatment for these patients and assess their evolution. Key Points • Right ventricular (RV) function and RV coupling with the pulmonary artery (RV-PA coupling) were worse in patients with RA in comparison to healthy controls. • Values of right ventricular systolic pressure (RVSP) were similar between RA-patients and non-RA controls. • Prevalence of normal RVSP, mild echocardiographic pulmonary hypertension (ePH), and pulmonary hypertension was similar between RA-patients and non-RA matched controls •Patients with RA and mild ePH had reduced RV-PA coupling in comparison with RA-patients with normal RVSP.