RhIII-Catalyzed C–H (Het)arylation/Vinylation of N‑2,6-Difluoroaryl Acrylamides

RhIII-catalyzed sp2 C–H cross-coupling of acrylamides with organoboron reactants has been accomplished using a commercially available N-2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability can...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2021-02, Vol.23 (3), p.656-662
Main Authors: Wang, Huai-Wei, Qiao, Yu-Han, Wu, Jia-Xue, Wang, Qiu-Ping, Tian, Meng-Xin, Li, Yong-Fei, Yao, Qing-Xia, Li, Da-Cheng, Dou, Jian-Min, Lu, Yi
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:RhIII-catalyzed sp2 C–H cross-coupling of acrylamides with organoboron reactants has been accomplished using a commercially available N-2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability can serve as the coupling partners. This transformation proceeds under moderate reaction conditions with excellent functional group tolerance and high regioselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c03688