Neuroanatomical changes in early Parkinson’s disease with mild cognitive impairment: a VBM study; the Parkinson’s Disease Cognitive Impairment Study (PaCoS)

• Published in: Neurological sciences 2021-09, Vol.42 (9), p.3723-3731
• Main Authors: Donzuso, Giulia, Monastero, Roberto, Cicero, Calogero E., Luca, Antonina, Mostile, Giovanni, Giuliano, Loretta, Baschi, Roberta, Caccamo, Maria, Gagliardo, Cesare, Palmucci, Stefano, Zappia, Mario, Nicoletti, Alessandra
• Format: Article
• Language: English
• Subjects: Anatomy; Atrophy; Brain architecture; Cerebellum; Cognitive ability; Correlation analysis; Cortex (parietal); Frontal gyrus; Magnetic resonance imaging; Medicine; Medicine & Public Health; Morphometry; Movement disorders; Neurodegenerative diseases; Neurology; Neuropsychology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Parkinson's disease; Patients; Psychiatry; Statistical analysis; Substantia grisea; Temporal lobe
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-020-05034-9

Introduction Mild cognitive impairment (MCI) is common in Parkinson’s disease (PD), but the underlying pathological mechanism has not been fully understood. Voxel-based morphometry could be used to evaluate regional atrophy and its relationship with cognitive performances in early PD-MCI. Patients and Methods One hundred and six patients with PD were recruited from a larger cohort of patients, the Parkinson’s Disease Cognitive Impairment Study (PaCoS). Subject underwent a T1-3D MRI and a complete clinical and neuropsychological evaluation. Patients were divided into PD with normal cognition (PD-NC) and PD-MCI according to the MDS level II criteria–modified for PD-MCI. A subgroup of early patients with short disease duration (≤ 2 years) was also identified. VBM analysis between PD-NC and PD-MCI and between early PD-NC and PD-MCI was performed using two-sample t tests with whole-brain statistical threshold of p