Management of choroid plexus tumours: A comprehensive study from a tertiary hospital

• Published in: Clinical neurology and neurosurgery 2021-02, Vol.201, p.106454-106454, Article 106454
• Main Authors: Konar, Subhas K., Kandregula, Sandeep, Beniwal, Manish, Sadashiva, Nishanth, Patel, Kautilya Rajendra Kumar, Nagesh, Madhusudhan, Rao, K.V.L.N., Vikas, V., Raj, Prabhu, Shashidhar, Abhinith, Uppar, Alok Mohan, Shukla, Dhaval, Indira Devi, B., Srinivas, Dwarakanath
• Format: Article
• Language: English
• Subjects: Age; Atypical choroid plexus papilloma; Brain cancer; Brain tumors; Carcinoma; Chemotherapy; Choroid plexus; Extent of resection; Histology; Histopathology; Hydrocephalus; Medical records; Neurology; Outcome; Papilloma; Radiation therapy; Regression analysis; Statistical analysis; Surgical outcomes; Survival; Tumors
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2020.106454

•Choroid plexus tumours (CPT) are rare intraventricular tumours (CPT) are rare intraventricular tumours.•Retrospectively, we analysed the factors affecting the outcome and the perioperative complications of the choroid plexus tumour.•A Cox regression analysis of predictors of mortality was done, and the extent of the resection is related to overall mortality (p = 0.01).•Perioperative complications and the overall outcome depend on patients’ demographics and tumour -related factors. Choroid plexus tumours (CPT) are rare intraventricular tumours representing less than 0.5 % of brain tumours. The tumour is commonly located in the supratentorial region, but the location varies depending on the age. We present our experience of managing these tumours in a tertiary hospital. Retrospectively, we reviewed our operative database and recruited 80 cases of CPT who underwent surgical treatment in our institute from 1995 to 2018. We analysed the factors affecting the outcome and the perioperative complications of the choroid plexus tumour. A total of 80 choroid plexus tumours were recruited in our retrospective review, of which 44 were choroid plexus papilloma (CPP), 13 were atypical choroid plexus tumours (ACPP), 23 were choroid plexus carcinomas (CPC). The mean age was 16.75 (SD 16.71) in the overall cohort. Males were found to be predominant in all tumour groups (M/F: 46/34). Headache was the most common symptom (52.5 %). Hydrocephalus was seen in 53.8 % of cases. The median overall survival was 89.88 months. Gross total resection was achieved in 62.5 % cases (n = 50/80), and near-total resection in 27. 5 % cases (n = 22/80). The median overall survival was 89.88 months. The median overall survival for CPP, ACPP, CPC was 106.83, 37.37, 36.19 months, respectively. Median Event-free survival was 65.83 months. A Cox regression analysis of predictors of overall survival of atypical CPP and CPC was done, in which age, sex, location, size, the extent of the resection, and complications were considered. The extent of the resection (p = 0.01) and the size (p = 0.02) were related to overall survival CPT’s are the rare intraventricular tumours, which requires aggressive resection strategies. The extent of resection offers survival benefit based on the histological grades.