Research advances for exosomal miRNAs detection in biosensing: From the massive study to the individual study

Exosomal miRNAs (exo-miRNAs) derived from cancer cell play a vital role in cancer development and can be considered as a potential biomarker for cancer diagnostic. However, the shortage of sensitive preparatory and analytical technologies limits their clinical applications. Thus, sensitive and relia...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2021-04, Vol.177, p.112962-112962, Article 112962
Main Authors: Wu, Yuan, Zhang, Ye, Zhang, Xiaohe, Luo, Shihua, Yan, Xiaohui, Qiu, Yurong, Zheng, Lei, Li, Ling
Format: Article
Language:English
Subjects:
Biomarkers
Biosensing Techniques
Exosomes - genetics
Humans
MicroRNAs - genetics
Neoplasms
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Summary:Exosomal miRNAs (exo-miRNAs) derived from cancer cell play a vital role in cancer development and can be considered as a potential biomarker for cancer diagnostic. However, the shortage of sensitive preparatory and analytical technologies limits their clinical applications. Thus, sensitive and reliable sensing of exo-miRNAs is essential in medical diagnostics. Mounting number of biosensor strategies are thus actively being proposed to deal with these challenges, including nanoparticle, isothermal amplification, and microfluidic chips. Moreover, some delivery strategies have been found for individual exo-miRNAs detection, such as membrane fusion, nano-sized probe and membrane denatured. Therefore, we summarize and discuss the recent progress of emerging biosensor assays for sensing exo-miRNAs. In addition, challenges and outlook for exo-miRNAs detection are considered. •We firstly summarize the pioneering studies and recent advances in exo-miRNAs detection using biosensor.•We review the studies of exo -miRNAs assays in biosensing from massive study to individual study..•We summarize multiple exo-miRNA detection methods information in a table.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2020.112962