Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method

We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DN...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021, Vol.170 (3), p.303-307
Main Authors: Timoshin, A. A., Shumaev, K. B., Lakomkin, V. L., Abramov, A. A., Ruuge, E. K.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Cysteine
Electron spin resonance
Internal Medicine
Iron
Laboratory Medicine
Lipophilic
Methods
N-Acetyl-L-cysteine
Pathology
Skin
Spectroscopy
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Summary:We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DNIC-Acc administration significantly increased the total level of NO in the lung and liver tissues of the animal, which was accompanied by a slight decrease in the mean BP (
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05056-z