Neuroprotective Effects of Heat-Killed Lactobacillus plantarum 200655 Isolated from Kimchi Against Oxidative Stress

Oxidative stress plays an important role in exacerbating neurodegenerative diseases, such as Alzheimer's disease, Parkinson’s disease, and Huntington’s disease. In a previous study, Lactobacillus plantarum 200655 was shown to possess probiotic and antioxidant potential. The current study aimed...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2021-06, Vol.13 (3), p.788-795
Main Authors: Cheon, Min-Jeong, Lee, Na-Kyoung, Paik, Hyun-Dong
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antioxidants
Apoptosis
Applied Microbiology
BAX protein
Bcl-2 protein
Brain-Derived Neurotrophic Factor
Caspase-3
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fermented Foods - microbiology
Gene expression
Heat
Hot Temperature
HT29 Cells
Humans
Huntingtons disease
Hydrogen peroxide
Hydrogen Peroxide - toxicity
Hydroxylase
Lactobacillus plantarum
Microbiology
Movement disorders
Neuroblasts
Neurodegenerative Diseases
Neuroprotection
Neuroprotective Agents - pharmacology
Neurotoxicity
Nutrition
Oxidative Stress
Parkinson's disease
Probiotics
Protein Science
Tyrosine 3-monooxygenase
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Summary:Oxidative stress plays an important role in exacerbating neurodegenerative diseases, such as Alzheimer's disease, Parkinson’s disease, and Huntington’s disease. In a previous study, Lactobacillus plantarum 200655 was shown to possess probiotic and antioxidant potential. The current study aimed to evaluate the neuroprotective effects of heat-killed L. plantarum 200655. We incubated intestinal cells (HT-29) with heat-killed L. plantarum 200655 in a conditioned medium (CM) and found that the brain-derived neurotrophic factor ( BDNF ) mRNA level was elevated in the HT-29 cells and the CM contained high concentrations of BDNF. The CM protected neuroblastoma cells (SH-SY5Y) from hydrogen peroxide (H 2 O 2 )-induced toxicity. Moreover, the CM increased BDNF and tyrosine hydroxylase ( TH ) mRNA expression and significantly reduced the apoptosis-related Bax / Bcl-2 ratio in H 2 O 2 -treated SH-SY5Y cells. At the protein level, the CM resulted in downregulation of caspase-3. These results indicate that L. plantarum 200655 might be used as a prophylactic functional ingredient to prevent neurodegenerative disease.
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-020-09740-w