Generation of HBsAg‐reactive T‐ and B‐cells following HBV vaccination in serological non‐responders under hemodialysis treatment

HBV vaccination is recommend for hemodialysis patients, but only 50–60% of the patients show seroconversion. HBV vaccine‐induced generation of HBV reactive T and B cells could be detected regardless of their capacity to mount a serological response, indicating that patients without seroconversion ar...

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Bibliographic Details
Published in:European journal of immunology 2021-05, Vol.51 (5), p.1278-1281
Main Authors: Roch, Toralf, Giesecke‐Thiel, Claudia, Blazquez‐Navarro, Arturo, Wehler, Patrizia, Thieme, Constantin J., Juelke, Kerstin, Grütz, Gerald, Hörstrup, Jan, Witzke, Oliver, Dittmer, Ulf, Stervbo, Ulrik, Reinke, Petra, Westhoff, Timm H., Babel, Nina
Format: Article
Language:English
Subjects:
antigen‐specific B cells
anti‐HBsAg titer
Hemodialysis
Hepatitis B surface antigen
hepatitis B virus
Immunization
Lymphocytes B
Lymphocytes T
renal diseases
Seroconversion
Serology
T cells
Vaccination
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Summary:HBV vaccination is recommend for hemodialysis patients, but only 50–60% of the patients show seroconversion. HBV vaccine‐induced generation of HBV reactive T and B cells could be detected regardless of their capacity to mount a serological response, indicating that patients without seroconversion are potentially protected by their HBV‐reactive T cell pool.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202048756