A Prelude to Biogermylene Chemistry

The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air‐, water‐, and culture‐medium‐stable germylene DPMGeOH (3; DPM=dipyrromethene ligand) and its potential biological application. Compound 3 exhibits antiproliferative effects comp...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-11, Vol.59 (48), p.21377-21381
Main Authors: Mahawar, Pritam, Wasson, Mishi Kaushal, Sharma, Mahendra Kumar, Jha, Chandan Kumar, Mukherjee, Goutam, Vivekanandan, Perumal, Nagendran, Selvarajan
Format: Article
Language:English
Subjects:
Animals
anti-tumor compounds
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic drugs
Antitumor agents
Apoptosis - drug effects
bioorganometallic chemistry
Cell culture
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Chlorocebus aethiops
Cisplatin
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Cytotoxicity
Drug Screening Assays, Antitumor
Epithelial cells
germylenes
Humans
Ligands
main-group chemistry
metallylenes
Microbial Sensitivity Tests
Molecular Structure
Toxicity
Vero Cells
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Summary:The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air‐, water‐, and culture‐medium‐stable germylene DPMGeOH (3; DPM=dipyrromethene ligand) and its potential biological application. Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anticancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low‐valent main‐group chemistry. The biological application of an air‐, water‐, and culture‐medium‐stable germylene is demonstrated. The compound DPMGeOH (DPM=dipyrromethene ligand) shows strong antiproliferative effects on human cancer cell lines but is only minimally toxic to normal epithelial cells.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202004551