What is the most anticipated change induced by treatment using gender‐affirming hormones in individuals with gender incongruence?

Objectives To identify the most eagerly anticipated change resulting from hormone therapy using gender‐affirming hormones for patients with gender incongruence undergoing a clinical trial. Methods Patients diagnosed with gender identity disorders based on the International Classification of Diseases...

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Bibliographic Details
Published in:International journal of urology 2021-05, Vol.28 (5), p.526-529
Main Authors: Masumori, Naoya, Baba, Tsuyoshi, Abe, Teruo, Niwa, Koji
Format: Article
Language:English
Subjects:
Androgens
Androgens - therapeutic use
Breast
Classification
Clinical trials
Endocrine therapy
Estrogens
Female
Gender
gender dysphoria
Gender Dysphoria - drug therapy
Gender Identity
gender incongruence
gender‐affirming hormone
hormonal therapy
Hormones
Humans
Japan
Male
Patients
the most anticipated change
Transgender Persons
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Summary:Objectives To identify the most eagerly anticipated change resulting from hormone therapy using gender‐affirming hormones for patients with gender incongruence undergoing a clinical trial. Methods Patients diagnosed with gender identity disorders based on the International Classification of Diseases 10th revision classification at three institutions in Japan for whom hormone therapy using gender‐affirming hormones was initiated were analyzed. They were asked what the most anticipated change was due to gender‐affirming hormone that they had thought of between giving informed consent and the first administration of the drug. Results The responders were 336 transgender men who were administered androgens and 48 transgender women who received estrogens. The median age at commencement of hormone therapy was 24 years for transgender men and 28 years for transgender women. For transgender men, the most frequent answer was cessation of menses (52.7%) followed by a deepened voice (32.4%). For transgender women, breast development (35.4%) was the most anticipated change, followed by gynoid fat deposition (29.2%). Conclusions Cessation of menses in transgender men and breast development/gynoid fat deposition in transgender women might represent primary end‐points in clinical trials evaluating the efficacy of hormonal treatment in these patients.
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.14499