Adjunctive steroids in adults with encephalitis: a propensity score analysis

Objective Adjuvant steroids have been used for the treatment of encephalitis, although there is limited data regarding its benefit. We described the use and impact of adjunctive steroids on adverse clinical outcomes (ACO) in adults with encephalitis. Methods Retrospective observational study of 230...

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Bibliographic Details
Published in:Journal of neurology 2021-06, Vol.268 (6), p.2151-2160
Main Authors: Allana, Ambreen, Samannodi, Mohammed, Hansen, Michael A., DeSantis, Stacia, Ho, Lauren T., Hasbun, Rodrigo
Format: Article
Language:English
Subjects:
Clinical outcomes
Edema
Encephalitis
Fever
Magnetic resonance imaging
Mechanical ventilation
Medicine
Medicine & Public Health
Neuroimaging
Neurological diseases
Neurology
Neuroradiology
Neurosciences
Original Communication
Patients
Steroid hormones
Substantia alba
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Summary:Objective Adjuvant steroids have been used for the treatment of encephalitis, although there is limited data regarding its benefit. We described the use and impact of adjunctive steroids on adverse clinical outcomes (ACO) in adults with encephalitis. Methods Retrospective observational study of 230 adults with encephalitis at two tertiary care hospital systems in Houston, Texas, between August 2008 and September 2017. An ACO was assessed at the time of death or discharge and defined as a Glasgow Outcome Scale 1–4. A propensity score analysis was performed. Results Out of 230 adult encephalitis patients enrolled, 121 (52.6%) received steroids. Adjunctive steroids were given more frequently to those who had focal neurological deficits ( P  = 0.01), required mechanical ventilation (MV) ( P  = 0.01), had intensive care unit admission ( P  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-021-10398-9