PAI-1 and tPA gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in a sample of Turkish population

The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphis...

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Published in:Journal of the Pakistan Medical Association 2020-12, Vol.70 (12(B)), p.2310-2315
Main Authors: Sunnetcioglu, Aysel, Berkoz, Mehmet, Yildirim, Metin, Bora, Gulhan, Yalin, Serap
Format: Article
Language:English
Subjects:
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism, Genetic
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - genetics
Tissue Plasminogen Activator
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container_issue 12(B)
container_start_page 2310
container_title Journal of the Pakistan Medical Association
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creator Sunnetcioglu, Aysel
Berkoz, Mehmet
Yildirim, Metin
Bora, Gulhan
Yalin, Serap
description The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects and 160 controls were investigated using PCR-RFLP and PCR methods, respectively. 4G allele frequency was 0.62 and 0.39 for COPD and control groups, respectively. 4G allele had an estimated 2.56- fold [95% CI = 1.85-3.53] increased risk of COPD. tPA I allele frequency was 0.55 and 0.50, for COPD and control groups, respectively. I allele had an estimated 1.19-fold [95% CI = 0.87-1.62] increased risk of COPD. PAI-1 4G/4G and 4G/5G genotypes seemed to play a key role in the pathophysiology of COPD in Turkish individuals.
doi_str_mv 10.5455/JPMA.250
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subjects Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism, Genetic
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - genetics
Tissue Plasminogen Activator
title PAI-1 and tPA gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in a sample of Turkish population
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