Delayed Bladder Perforation Related to Immediate Single Dose Intravesical Doxorubicin Instillation After TURBT: A Case Report and Literature Review

• Published in: Clinical medicine insights. Case reports 2021, Vol.14, p.1179547620986158-1179547620986158
• Main Authors: Alrabadi, Adel, Abuhamad, Mohannad, Mansi, Hammam, Alhamss, Sohaib, Bustami, Nadwa, Al Demour, Saddam, Al-Abbadi, Mousa A
• Format: Report
• Language: English
• ISSN: 1179-5476; 1179-5476
• DOI: 10.1177/1179547620986158

INTRODUCTIONIntravesical chemotherapy instillation immediately after tumor resection is a well-known practice in the management of non-muscle invasive bladder cancer. Despite being largely well tolerated in most cases, it is not devoid of severe and life-threatening complications. CASE PRESENTATIONWe present an unusual case of bladder perforation that happened 2 weeks after bladder tumor resection. The patient had received single dose intra-vesical instillation of doxorubicin after TUR-BT. Conservative managements failed to achieve bladder healing; as a result, open surgical repair was performed. To the best of our knowledge, this is the first reported case of bladder perforation after intra-vesical doxorubicin instillation. CONCLUSIONThe occurrence of such a rare serious complication in a mostly safe intervention must be taken into consideration. A high index of suspicion, timely management, and proceeding to more invasive surgical treatments when necessary are cornerstones in the management and preserving the bladder.