Argireline: Needle‐Free Botox as Analytical Challenge

Argireline‐containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox‐like effect. Therefore, it is used as a safe needle‐free alt...

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Bibliographic Details
Published in:Chemistry & biodiversity 2021-03, Vol.18 (3), p.e2000992-n/a
Main Authors: Kluczyk, Alicja, Ludwiczak, Julita, Modzel, Maciej, Kuczer, Mariola, Cebrat, Marek, Biernat, Monika, Bąchor, Remigiusz
Format: Article
Language:English
Subjects:
amino acids
anti-wrinkle cosmetics
argireline
Botulinum toxin
cosmeceutical peptides
Cosmetics
High performance liquid chromatography
high resolution mass spectrometry
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Methionine
methionine oxidation
Neurotransmitters
Oxidation
peptides
Public concern
Sample preparation
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Summary:Argireline‐containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox‐like effect. Therefore, it is used as a safe needle‐free alternative to botox treatment. In this work we investigated the presence of Argireline in cosmetic creams and sera by application of reversed phase liquid chromatography and tandem mass spectrometry (RP‐HPLC/MS and MS/MS). The analysis revealed the presence of argireline and its oxidized form in several different cosmetics. The methionine residue in Argireline sequence was indicated as oxidation point according to neutral loss MS studies. The developed sample preparation strategy minimizes and monitors methionine oxidation, bringing to our attention the question of impact of ingredients on the stability of cosmetic product.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202000992