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Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against . As a result, we discovered several analogues that both inhibit and di...

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Bibliographic Details
Published in:MedChemComm 2020-01, Vol.11 (1), p.92-97
Main Authors: Brackett, Sara M, Cox, Karlie E, Barlock, Samantha L, Huggins, William M, Ackart, David F, Bassaraba, Randall J, Melander, Roberta J, Melander, Christian
Format: Article
Language:English
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Summary:The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against . As a result, we discovered several analogues that both inhibit and disperse biofilms.
ISSN:2632-8682
2040-2503
2632-8682
2040-2511
DOI:10.1039/c9md00466a