Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate

Mitochondrial quality control is crucial for sustaining cellular maintenance. Mitochondrial Ca2+ plays an important role in the maintenance of mitochondrial quality control through regulation of mitochondrial dynamics, mitophagy and mitochondrial biogenesis for preserving cellular homeostasis. The r...

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Bibliographic Details
Published in:Mitochondrion 2021-03, Vol.57, p.230-240
Main Authors: Patra, Srimanta, Mahapatra, Kewal Kumar, Praharaj, Prakash Priyadarshi, Panigrahi, Debasna Pritimanjari, Bhol, Chandra Sekhar, Mishra, Soumya Ranjan, Behera, Bishnu Prasad, Singh, Amruta, Jena, Mrutyunjay, Bhutia, Sujit Kumar
Format: Article
Language:English
Subjects:
Cancer
Mitochondrial biogenesis
Mitochondrial Ca2
Mitochondrial quality control
Mitophagy
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Summary:Mitochondrial quality control is crucial for sustaining cellular maintenance. Mitochondrial Ca2+ plays an important role in the maintenance of mitochondrial quality control through regulation of mitochondrial dynamics, mitophagy and mitochondrial biogenesis for preserving cellular homeostasis. The regulation of this dynamic interlink between these mitochondrial networks and mitochondrial Ca2+ appears indispensable for the adaptation of cells under external stimuli. Moreover, dysregulation of mitochondrial Ca2+ divulges impaired mitochondrial control that results in several pathological conditions such as cancer. Hence this review untangles the interplay between mitochondrial Ca2+ and quality control that govern mitochondrial health and mitochondrial coordinates in the development of cancer.
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2021.01.002