Skeletal muscle depletion and nutrition support affected postoperative complications in patients who underwent pancreatoduodenectomy

• Published in: European journal of clinical nutrition 2021-08, Vol.75 (8), p.1218-1226
• Main Authors: Duan, Kaipeng, Gao, Xin, Wei, Luxin, Gong, Mengting, Feng, Bin, Zhou, Jin, Zhu, Dongming
• Format: Article
• Language: English
• Subjects: 692/308; 692/699/1702/295; Body composition; Clinical Nutrition; Complications; Complications and side effects; Computed tomography; Density; Depletion; Epidemiology; Health aspects; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Muscles; Musculoskeletal system; Nutrition; Nutrition research; Pancreaticoduodenectomy; Parenteral feeding; Parenteral nutrition; Parenteral therapy; Proteins; Public Health; Skeletal muscle; Subgroups; Surgery
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/s41430-020-00851-9

Background Body composition has been shown closely related to the outcome in surgical patients. The aim of the present study was to investigate whether preoperative skeletal muscle condition and postoperative nutrition would affect major complications in patients underwent pancreaticoduodenectomy (PD). Methods This retrospective study included 265 patients underwent PD. Body composition data was extracted from the L3 level of the preoperative CT scan. Univariable and multivariable regression analyses were performed to investigate correlations between body composition data and postoperative complications. Furthermore, a subgroup analysis was conducted to explore the relationship between postoperative nutrition strategy and the outcome. Results Of all the 265 patients, major complications occurred in 81 patients (30.6%). Cutoff values for skeletal muscle depletion were defined by ROC curve analysis from postoperative complications in skeletal muscle index (SMI) (male 47.32 cm 2 /m 2 and female 40.65 cm 2 /m 2 ). Univariable analysis and multivariable regression revealed age (OR 1.49, 95% CI 1.22–1.83, p  = 0.026), SMI (OR 0.77, 95% CI 0.51–0.94, p  = 0.015) and skeletal muscle density (SMD) (OR 0.85, 95% CI 0.64–1.03, p  = 0.029) were independent predictors for major complications. Subgroup analysis showed the initial parenteral nutrition time (IPNT) (OR 1.89, 95% CI 1.43–2.49, p  = 0.032) and average protein delivery (APD) (OR 0.76, 95% CI 0.53–0.89, p  = 0.021) were significantly associated with major complications in patients with lower SMI. Conclusions Preoperative skeletal muscle index and density were independently associated with major complications in patients underwent PD. In patients with lower SMI, early parenteral nutrition and higher protein delivery were related to better outcome.