Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs

Purpose To evaluate the safety and feasibility of a newly designed 125 I brachytherapy ureteral stent (BUS) in normal dogs. Methods A BUS loaded with 10 125 I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross obser...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2021-04, Vol.147 (4), p.1115-1123
Main Authors: Jiao, Dechao, Yao, Yuan, Xu, Kaihao, Lei, Qinyu, Li, Zongming, Han, Xinwei, Ren, Jianzhuang
Format: Article
Language:English
Subjects:
Animals
Brachytherapy
Brachytherapy - methods
Cancer Research
Caspase-3
Cell proliferation
Collagen (type I)
Dogs
Dose-Response Relationship, Radiation
Epithelial cells
Female
Fibrosis
Hematology
Implants
Internal Medicine
Iodine Radioisotopes - therapeutic use
Male
Medicine
Medicine & Public Health
mRNA
Oncology
Original Article – Cancer Research
Proliferating cell nuclear antigen
Radiation therapy
Seeds
Stents
Surgery
Ureter
Ureter - surgery
Ureteral Diseases - pathology
Ureteral Diseases - radiotherapy
Ureteral stents
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Summary:Purpose To evaluate the safety and feasibility of a newly designed 125 I brachytherapy ureteral stent (BUS) in normal dogs. Methods A BUS loaded with 10 125 I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross observations, cumulative radiation doses, tissue reaction assessed by hematoxylin–eosin/Masson staining, mRNA analysis by RT-qPCR and protein expression of Caspase-3, Collagen I, PCNA, and α-SMA were performed at 2, 4 and 8 weeks. Results The BUS was implanted successfully in all dogs (27/27) without surgery-related death. The ureter diameter and radiation injury score increased along with radiation accumulation ( p  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-021-03513-w