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Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs
Purpose To evaluate the safety and feasibility of a newly designed 125 I brachytherapy ureteral stent (BUS) in normal dogs. Methods A BUS loaded with 10 125 I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross obser...
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| Published in: | Journal of cancer research and clinical oncology 2021-04, Vol.147 (4), p.1115-1123 |
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| Main Authors: | , , , , , , |
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| container_issue | 4 |
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| container_title | Journal of cancer research and clinical oncology |
| container_volume | 147 |
| creator | Jiao, Dechao Yao, Yuan Xu, Kaihao Lei, Qinyu Li, Zongming Han, Xinwei Ren, Jianzhuang |
| description | Purpose
To evaluate the safety and feasibility of a newly designed
125
I brachytherapy ureteral stent (BUS) in normal dogs.
Methods
A BUS loaded with 10
125
I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross observations, cumulative radiation doses, tissue reaction assessed by hematoxylin–eosin/Masson staining, mRNA analysis by RT-qPCR and protein expression of Caspase-3, Collagen I, PCNA, and α-SMA were performed at 2, 4 and 8 weeks.
Results
The BUS was implanted successfully in all dogs (27/27) without surgery-related death. The ureter diameter and radiation injury score increased along with radiation accumulation (
p
|
| doi_str_mv | 10.1007/s00432-021-03513-w |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2480754203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2480754203</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-574ecfb6a0bfa5ab02fd1cb14a56ce635446bf56bbd38f0fb3ccba6d30b0847c3</originalsourceid><addsrcrecordid>eNp9kLtOAzEQRS0EIiHwAxTIEg3Nwvi5CR2KeEmRaKChsWyvHRZt1sHeJcrf4xAeEgWVPTPnXnsuQscEzglAeZEAOKMFUFIAE4QVqx00JJsWYUzsoiGQkhSCEjlABym9Qq5FSffRgDE-oXzChuj5vn13qavnuqtDi4PHGrfh3TXYRG1f1t2Li3q5xn10Xb41OHWu7S5xF-vPoq9ql3BWtiEucsc4PW8crsI8HaI9r5vkjr7OEXq6uX6c3hWzh9v76dWssKwUXSFK7qw3UoPxWmgD1FfEGsK1kNZJJjiXxgtpTMXGHrxh1hotKwYGxry0bITOtr7LGN76vIxa1Mm6ptGtC31SlI-hFJwCy-jpH_Q19LHNv1NUAMixnIhJpuiWsjGkFJ1Xy1gvdFwrAmqTvNomr3Ly6jN5tcqiky_r3ixc9SP5jjoDbAukPGrnLv6-_Y_tB-WQkDk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2500686959</pqid></control><display><type>article</type><title>Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs</title><source>Springer Nature</source><creator>Jiao, Dechao ; Yao, Yuan ; Xu, Kaihao ; Lei, Qinyu ; Li, Zongming ; Han, Xinwei ; Ren, Jianzhuang</creator><creatorcontrib>Jiao, Dechao ; Yao, Yuan ; Xu, Kaihao ; Lei, Qinyu ; Li, Zongming ; Han, Xinwei ; Ren, Jianzhuang</creatorcontrib><description>Purpose
To evaluate the safety and feasibility of a newly designed
125
I brachytherapy ureteral stent (BUS) in normal dogs.
Methods
A BUS loaded with 10
125
I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross observations, cumulative radiation doses, tissue reaction assessed by hematoxylin–eosin/Masson staining, mRNA analysis by RT-qPCR and protein expression of Caspase-3, Collagen I, PCNA, and α-SMA were performed at 2, 4 and 8 weeks.
Results
The BUS was implanted successfully in all dogs (27/27) without surgery-related death. The ureter diameter and radiation injury score increased along with radiation accumulation (
p
< 0.05). Histopathologic analysis showed necrotic tissue and lateral fibrosis to different extents in the ureteral walls that gradually increased in all groups (
p
< 0.05); however, epithelial cell proliferation in groups A and B was lighter than that in the control group (
p
< 0.05).
Conclusion
Placement of the newly designed
125
I BUS was safe and feasible in dogs, and clinical studies are required to test its use in humans.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-021-03513-w</identifier><identifier>PMID: 33492493</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Brachytherapy ; Brachytherapy - methods ; Cancer Research ; Caspase-3 ; Cell proliferation ; Collagen (type I) ; Dogs ; Dose-Response Relationship, Radiation ; Epithelial cells ; Female ; Fibrosis ; Hematology ; Implants ; Internal Medicine ; Iodine Radioisotopes - therapeutic use ; Male ; Medicine ; Medicine & Public Health ; mRNA ; Oncology ; Original Article – Cancer Research ; Proliferating cell nuclear antigen ; Radiation therapy ; Seeds ; Stents ; Surgery ; Ureter ; Ureter - surgery ; Ureteral Diseases - pathology ; Ureteral Diseases - radiotherapy ; Ureteral stents</subject><ispartof>Journal of cancer research and clinical oncology, 2021-04, Vol.147 (4), p.1115-1123</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-574ecfb6a0bfa5ab02fd1cb14a56ce635446bf56bbd38f0fb3ccba6d30b0847c3</citedby><cites>FETCH-LOGICAL-c375t-574ecfb6a0bfa5ab02fd1cb14a56ce635446bf56bbd38f0fb3ccba6d30b0847c3</cites><orcidid>0000-0003-4460-8619</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33492493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiao, Dechao</creatorcontrib><creatorcontrib>Yao, Yuan</creatorcontrib><creatorcontrib>Xu, Kaihao</creatorcontrib><creatorcontrib>Lei, Qinyu</creatorcontrib><creatorcontrib>Li, Zongming</creatorcontrib><creatorcontrib>Han, Xinwei</creatorcontrib><creatorcontrib>Ren, Jianzhuang</creatorcontrib><title>Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
To evaluate the safety and feasibility of a newly designed
125
I brachytherapy ureteral stent (BUS) in normal dogs.
Methods
A BUS loaded with 10
125
I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross observations, cumulative radiation doses, tissue reaction assessed by hematoxylin–eosin/Masson staining, mRNA analysis by RT-qPCR and protein expression of Caspase-3, Collagen I, PCNA, and α-SMA were performed at 2, 4 and 8 weeks.
Results
The BUS was implanted successfully in all dogs (27/27) without surgery-related death. The ureter diameter and radiation injury score increased along with radiation accumulation (
p
< 0.05). Histopathologic analysis showed necrotic tissue and lateral fibrosis to different extents in the ureteral walls that gradually increased in all groups (
p
< 0.05); however, epithelial cell proliferation in groups A and B was lighter than that in the control group (
p
< 0.05).
Conclusion
Placement of the newly designed
125
I BUS was safe and feasible in dogs, and clinical studies are required to test its use in humans.</description><subject>Animals</subject><subject>Brachytherapy</subject><subject>Brachytherapy - methods</subject><subject>Cancer Research</subject><subject>Caspase-3</subject><subject>Cell proliferation</subject><subject>Collagen (type I)</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Epithelial cells</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Hematology</subject><subject>Implants</subject><subject>Internal Medicine</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>mRNA</subject><subject>Oncology</subject><subject>Original Article – Cancer Research</subject><subject>Proliferating cell nuclear antigen</subject><subject>Radiation therapy</subject><subject>Seeds</subject><subject>Stents</subject><subject>Surgery</subject><subject>Ureter</subject><subject>Ureter - surgery</subject><subject>Ureteral Diseases - pathology</subject><subject>Ureteral Diseases - radiotherapy</subject><subject>Ureteral stents</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOAzEQRS0EIiHwAxTIEg3Nwvi5CR2KeEmRaKChsWyvHRZt1sHeJcrf4xAeEgWVPTPnXnsuQscEzglAeZEAOKMFUFIAE4QVqx00JJsWYUzsoiGQkhSCEjlABym9Qq5FSffRgDE-oXzChuj5vn13qavnuqtDi4PHGrfh3TXYRG1f1t2Li3q5xn10Xb41OHWu7S5xF-vPoq9ql3BWtiEucsc4PW8crsI8HaI9r5vkjr7OEXq6uX6c3hWzh9v76dWssKwUXSFK7qw3UoPxWmgD1FfEGsK1kNZJJjiXxgtpTMXGHrxh1hotKwYGxry0bITOtr7LGN76vIxa1Mm6ptGtC31SlI-hFJwCy-jpH_Q19LHNv1NUAMixnIhJpuiWsjGkFJ1Xy1gvdFwrAmqTvNomr3Ly6jN5tcqiky_r3ixc9SP5jjoDbAukPGrnLv6-_Y_tB-WQkDk</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Jiao, Dechao</creator><creator>Yao, Yuan</creator><creator>Xu, Kaihao</creator><creator>Lei, Qinyu</creator><creator>Li, Zongming</creator><creator>Han, Xinwei</creator><creator>Ren, Jianzhuang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4460-8619</orcidid></search><sort><creationdate>20210401</creationdate><title>Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs</title><author>Jiao, Dechao ; Yao, Yuan ; Xu, Kaihao ; Lei, Qinyu ; Li, Zongming ; Han, Xinwei ; Ren, Jianzhuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-574ecfb6a0bfa5ab02fd1cb14a56ce635446bf56bbd38f0fb3ccba6d30b0847c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Brachytherapy</topic><topic>Brachytherapy - methods</topic><topic>Cancer Research</topic><topic>Caspase-3</topic><topic>Cell proliferation</topic><topic>Collagen (type I)</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Epithelial cells</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Hematology</topic><topic>Implants</topic><topic>Internal Medicine</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>mRNA</topic><topic>Oncology</topic><topic>Original Article – Cancer Research</topic><topic>Proliferating cell nuclear antigen</topic><topic>Radiation therapy</topic><topic>Seeds</topic><topic>Stents</topic><topic>Surgery</topic><topic>Ureter</topic><topic>Ureter - surgery</topic><topic>Ureteral Diseases - pathology</topic><topic>Ureteral Diseases - radiotherapy</topic><topic>Ureteral stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiao, Dechao</creatorcontrib><creatorcontrib>Yao, Yuan</creatorcontrib><creatorcontrib>Xu, Kaihao</creatorcontrib><creatorcontrib>Lei, Qinyu</creatorcontrib><creatorcontrib>Li, Zongming</creatorcontrib><creatorcontrib>Han, Xinwei</creatorcontrib><creatorcontrib>Ren, Jianzhuang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiao, Dechao</au><au>Yao, Yuan</au><au>Xu, Kaihao</au><au>Lei, Qinyu</au><au>Li, Zongming</au><au>Han, Xinwei</au><au>Ren, Jianzhuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>147</volume><issue>4</issue><spage>1115</spage><epage>1123</epage><pages>1115-1123</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
To evaluate the safety and feasibility of a newly designed
125
I brachytherapy ureteral stent (BUS) in normal dogs.
Methods
A BUS loaded with 10
125
I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C: 0 mCi) was designed and tested in 27 normal beagle dogs. Routine blood tests, gross observations, cumulative radiation doses, tissue reaction assessed by hematoxylin–eosin/Masson staining, mRNA analysis by RT-qPCR and protein expression of Caspase-3, Collagen I, PCNA, and α-SMA were performed at 2, 4 and 8 weeks.
Results
The BUS was implanted successfully in all dogs (27/27) without surgery-related death. The ureter diameter and radiation injury score increased along with radiation accumulation (
p
< 0.05). Histopathologic analysis showed necrotic tissue and lateral fibrosis to different extents in the ureteral walls that gradually increased in all groups (
p
< 0.05); however, epithelial cell proliferation in groups A and B was lighter than that in the control group (
p
< 0.05).
Conclusion
Placement of the newly designed
125
I BUS was safe and feasible in dogs, and clinical studies are required to test its use in humans.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33492493</pmid><doi>10.1007/s00432-021-03513-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4460-8619</orcidid></addata></record> |
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| ispartof | Journal of cancer research and clinical oncology, 2021-04, Vol.147 (4), p.1115-1123 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2480754203 |
| source | Springer Nature |
| subjects | Animals Brachytherapy Brachytherapy - methods Cancer Research Caspase-3 Cell proliferation Collagen (type I) Dogs Dose-Response Relationship, Radiation Epithelial cells Female Fibrosis Hematology Implants Internal Medicine Iodine Radioisotopes - therapeutic use Male Medicine Medicine & Public Health mRNA Oncology Original Article – Cancer Research Proliferating cell nuclear antigen Radiation therapy Seeds Stents Surgery Ureter Ureter - surgery Ureteral Diseases - pathology Ureteral Diseases - radiotherapy Ureteral stents |
| title | Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs |
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