Recent progresses in the pharmacological activities of caffeic acid phenethyl ester

• Published in: Naunyn-Schmiedeberg's archives of pharmacology 2021-07, Vol.394 (7), p.1327-1339
• Main Authors: Lv, Lili, Cui, Honghua, Ma, Zhiming, Liu, Xin, Yang, Longfei
• Format: Article
• Language: English
• Subjects: Acids; Androgens; Angiogenesis; Animals; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antioxidants; Antioxidants - isolation & purification; Antioxidants - pharmacology; Antioxidants - therapeutic use; Apoptosis; Autophagy; Biomedical and Life Sciences; Biomedicine; Breast cancer; Caffeic acid; Caffeic Acids - isolation & purification; Caffeic Acids - pharmacology; Caffeic Acids - therapeutic use; Cancer therapies; Cell cycle; Cell growth; Cervical cancer; Chemotherapy; Clinical trials; Cytotoxicity; Digestive system; Drug Development - methods; Drug Development - trends; Drug dosages; Drug resistance; Flavonoids; Genes; Hematology; Humans; Inflammation; Kinases; Metastasis; Natural products; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurosciences; NF-kappa B - antagonists & inhibitors; NF-kappa B - metabolism; NF-κB protein; Ovarian cancer; Pharmacology/Toxicology; Phenylethyl Alcohol - analogs & derivatives; Phenylethyl Alcohol - isolation & purification; Phenylethyl Alcohol - pharmacology; Phenylethyl Alcohol - therapeutic use; Phosphorylation; Propolis; Proteins; Review Article; Tumors
• ISSN: 0028-1298; 1432-1912
• DOI: 10.1007/s00210-021-02054-w

The past decades have seen a growing interest in natural products. Caffeic acid phenethyl ester (CAPE), a flavonoid isolated from honeybee propolis, has shown multiple pharmacological potentials, including anti-cancer, anti-inflammatory, antioxidant, antibacterial, antifungal, and protective effects on nervous systems and multiple organs, since it was found as a potent nuclear factor κB (NF-κB) inhibitor. This review summarizes the advances in these beneficial effects of CAPE, as well as the underlying mechanisms, and proposes that CAPE offers an opportunity for developing therapeutics in multiple diseases. However, clinical trials on CAPE are necessary and encouraged to obtain certain clinically relevant conclusions.