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The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker
Background The aims of this study were to find the normal value of fronto-temporal horn ratio (FTHR) as a marker of ventriculomegaly on cranial ultrasound (CUS) in premature newborns and the relation to white matter injury (WMI) and cerebral palsy (CP). Methods This is a retrospective study of newbo...
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| Published in: | Pediatric research 2021-05, Vol.89 (7), p.1715-1723 |
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| container_issue | 7 |
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| container_title | Pediatric research |
| container_volume | 89 |
| creator | Obeid, Rawad Jacobs, Marni Chang, Taeun Massaro, An N. Bluth, Eresha Murnick, Jonathan G. Bulas, Dorothy Bandarkar, Anjum Oluigbo, Chima Penn, Anna A. |
| description | Background
The aims of this study were to find the normal value of fronto-temporal horn ratio (FTHR) as a marker of ventriculomegaly on cranial ultrasound (CUS) in premature newborns and the relation to white matter injury (WMI) and cerebral palsy (CP).
Methods
This is a retrospective study of newborns admitted between 2011 and 2014. Inclusion criteria were: (1) gestation |
| doi_str_mv | 10.1038/s41390-020-01337-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2482669974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2547177994</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-33815e01c82f389cf99b86a77d7696a4c2b6f38454bcd6fa8962f0004775bde83</originalsourceid><addsrcrecordid>eNp9kc1u3SAQhVGVKrlN8wJdVEjZdOMWDDbQXRX1T4rUTbpGGI8TJzbcDJDmvn1Jb9JIXXSB0DDfOczoEPKGs_ecCf0hSS4Ma1hbDxdCNfcvyIZ3opZSqgOyYUzwRhijj8irlK4Z47LT8pAcCdExaTqzIfniCmjJ8zLnHY0TzbWcMIYcmwzrNqJb6FXEQNHlOdIYqEcX5vpalowuxRJGOge6RVhdLgg0wK-hCtJH6ugdhIyzL0tc4dItO7o6vAF8TV5Obklw8ngfk59fPl-cfWvOf3z9fvbpvPGSm9wIoXkHjHvdTkIbPxkz6N4pNare9E76duhrQ3Zy8GM_OW36dmKMSaW6YQQtjsm7ve8W422BlO06Jw_L4gLEkmwrddv3xihZ0dN_0OtYMNTpbNtJxZUy5oFq95THmBLCZLc41512ljP7kIndZ2JrJvZPJva-it4-WpdhhfGv5CmECog9kGorXAI-__0f29-4Tpj-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547177994</pqid></control><display><type>article</type><title>The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker</title><source>Springer Nature</source><creator>Obeid, Rawad ; Jacobs, Marni ; Chang, Taeun ; Massaro, An N. ; Bluth, Eresha ; Murnick, Jonathan G. ; Bulas, Dorothy ; Bandarkar, Anjum ; Oluigbo, Chima ; Penn, Anna A.</creator><creatorcontrib>Obeid, Rawad ; Jacobs, Marni ; Chang, Taeun ; Massaro, An N. ; Bluth, Eresha ; Murnick, Jonathan G. ; Bulas, Dorothy ; Bandarkar, Anjum ; Oluigbo, Chima ; Penn, Anna A.</creatorcontrib><description>Background
The aims of this study were to find the normal value of fronto-temporal horn ratio (FTHR) as a marker of ventriculomegaly on cranial ultrasound (CUS) in premature newborns and the relation to white matter injury (WMI) and cerebral palsy (CP).
Methods
This is a retrospective study of newborns admitted between 2011 and 2014. Inclusion criteria were: (1) gestation <29 weeks, (2) birth weight ≤1500 g, (3) referred within 7 days of life, (4) at least two CUS preformed, (5) brain magnetic resonance imaging (MRI) at term age-equivalent. Intraventricular hemorrhage (IVH) grade was identified and FTHR was measured on all CUS. WMI on MRI was evaluated through (1) injury score (Kidokoro 2013) and (2) fractional anisotropy (FA) on the MRI diffusion tensor imaging. CP was estimated using the gross motor function classification system (GMFCS).
Results
One hundred neonates met the inclusion criteria: 37 with no IVH, 36 with IVH grade 1–2, and 27 with IVH grade 3–4. The FTHR cut-point of 0.51 had the highest sensitivity and specificity for moderate-to-severe WMI. In the IVH grade 3–4 group, the elevated FTHR correlated with lower FA and higher GMFCS.
Conclusions
FTHR is a useful quantitative biomarker of ventriculomegaly in preterm newborns. It may help standardize ventricular measurement and direct intervention.
Impact
The fronto-temporal horn ratio has the potential to become a standardized tool that can provide an actionable measure to direct intervention for post-hemorrhagic ventricular dilation.
This current study will provide the basis of a future clinical trial to optimize intervention timing to decrease the risk of white matter injury in this vulnerable population.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-020-01337-x</identifier><identifier>PMID: 33504959</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Biomarkers ; Clinical Research Article ; Humans ; Hydrocephalus - diagnostic imaging ; Hydrocephalus - pathology ; Infant, Newborn ; Infant, Premature ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Retrospective Studies ; Temporal Lobe - diagnostic imaging ; Temporal Lobe - pathology ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>Pediatric research, 2021-05, Vol.89 (7), p.1715-1723</ispartof><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2021</rights><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-33815e01c82f389cf99b86a77d7696a4c2b6f38454bcd6fa8962f0004775bde83</citedby><cites>FETCH-LOGICAL-c419t-33815e01c82f389cf99b86a77d7696a4c2b6f38454bcd6fa8962f0004775bde83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33504959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obeid, Rawad</creatorcontrib><creatorcontrib>Jacobs, Marni</creatorcontrib><creatorcontrib>Chang, Taeun</creatorcontrib><creatorcontrib>Massaro, An N.</creatorcontrib><creatorcontrib>Bluth, Eresha</creatorcontrib><creatorcontrib>Murnick, Jonathan G.</creatorcontrib><creatorcontrib>Bulas, Dorothy</creatorcontrib><creatorcontrib>Bandarkar, Anjum</creatorcontrib><creatorcontrib>Oluigbo, Chima</creatorcontrib><creatorcontrib>Penn, Anna A.</creatorcontrib><title>The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
The aims of this study were to find the normal value of fronto-temporal horn ratio (FTHR) as a marker of ventriculomegaly on cranial ultrasound (CUS) in premature newborns and the relation to white matter injury (WMI) and cerebral palsy (CP).
Methods
This is a retrospective study of newborns admitted between 2011 and 2014. Inclusion criteria were: (1) gestation <29 weeks, (2) birth weight ≤1500 g, (3) referred within 7 days of life, (4) at least two CUS preformed, (5) brain magnetic resonance imaging (MRI) at term age-equivalent. Intraventricular hemorrhage (IVH) grade was identified and FTHR was measured on all CUS. WMI on MRI was evaluated through (1) injury score (Kidokoro 2013) and (2) fractional anisotropy (FA) on the MRI diffusion tensor imaging. CP was estimated using the gross motor function classification system (GMFCS).
Results
One hundred neonates met the inclusion criteria: 37 with no IVH, 36 with IVH grade 1–2, and 27 with IVH grade 3–4. The FTHR cut-point of 0.51 had the highest sensitivity and specificity for moderate-to-severe WMI. In the IVH grade 3–4 group, the elevated FTHR correlated with lower FA and higher GMFCS.
Conclusions
FTHR is a useful quantitative biomarker of ventriculomegaly in preterm newborns. It may help standardize ventricular measurement and direct intervention.
Impact
The fronto-temporal horn ratio has the potential to become a standardized tool that can provide an actionable measure to direct intervention for post-hemorrhagic ventricular dilation.
This current study will provide the basis of a future clinical trial to optimize intervention timing to decrease the risk of white matter injury in this vulnerable population.</description><subject>Biomarkers</subject><subject>Clinical Research Article</subject><subject>Humans</subject><subject>Hydrocephalus - diagnostic imaging</subject><subject>Hydrocephalus - pathology</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Temporal Lobe - pathology</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u3SAQhVGVKrlN8wJdVEjZdOMWDDbQXRX1T4rUTbpGGI8TJzbcDJDmvn1Jb9JIXXSB0DDfOczoEPKGs_ecCf0hSS4Ma1hbDxdCNfcvyIZ3opZSqgOyYUzwRhijj8irlK4Z47LT8pAcCdExaTqzIfniCmjJ8zLnHY0TzbWcMIYcmwzrNqJb6FXEQNHlOdIYqEcX5vpalowuxRJGOge6RVhdLgg0wK-hCtJH6ugdhIyzL0tc4dItO7o6vAF8TV5Obklw8ngfk59fPl-cfWvOf3z9fvbpvPGSm9wIoXkHjHvdTkIbPxkz6N4pNare9E76duhrQ3Zy8GM_OW36dmKMSaW6YQQtjsm7ve8W422BlO06Jw_L4gLEkmwrddv3xihZ0dN_0OtYMNTpbNtJxZUy5oFq95THmBLCZLc41512ljP7kIndZ2JrJvZPJva-it4-WpdhhfGv5CmECog9kGorXAI-__0f29-4Tpj-</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Obeid, Rawad</creator><creator>Jacobs, Marni</creator><creator>Chang, Taeun</creator><creator>Massaro, An N.</creator><creator>Bluth, Eresha</creator><creator>Murnick, Jonathan G.</creator><creator>Bulas, Dorothy</creator><creator>Bandarkar, Anjum</creator><creator>Oluigbo, Chima</creator><creator>Penn, Anna A.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210501</creationdate><title>The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker</title><author>Obeid, Rawad ; Jacobs, Marni ; Chang, Taeun ; Massaro, An N. ; Bluth, Eresha ; Murnick, Jonathan G. ; Bulas, Dorothy ; Bandarkar, Anjum ; Oluigbo, Chima ; Penn, Anna A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-33815e01c82f389cf99b86a77d7696a4c2b6f38454bcd6fa8962f0004775bde83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Clinical Research Article</topic><topic>Humans</topic><topic>Hydrocephalus - diagnostic imaging</topic><topic>Hydrocephalus - pathology</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Temporal Lobe - pathology</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obeid, Rawad</creatorcontrib><creatorcontrib>Jacobs, Marni</creatorcontrib><creatorcontrib>Chang, Taeun</creatorcontrib><creatorcontrib>Massaro, An N.</creatorcontrib><creatorcontrib>Bluth, Eresha</creatorcontrib><creatorcontrib>Murnick, Jonathan G.</creatorcontrib><creatorcontrib>Bulas, Dorothy</creatorcontrib><creatorcontrib>Bandarkar, Anjum</creatorcontrib><creatorcontrib>Oluigbo, Chima</creatorcontrib><creatorcontrib>Penn, Anna A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obeid, Rawad</au><au>Jacobs, Marni</au><au>Chang, Taeun</au><au>Massaro, An N.</au><au>Bluth, Eresha</au><au>Murnick, Jonathan G.</au><au>Bulas, Dorothy</au><au>Bandarkar, Anjum</au><au>Oluigbo, Chima</au><au>Penn, Anna A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>89</volume><issue>7</issue><spage>1715</spage><epage>1723</epage><pages>1715-1723</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
The aims of this study were to find the normal value of fronto-temporal horn ratio (FTHR) as a marker of ventriculomegaly on cranial ultrasound (CUS) in premature newborns and the relation to white matter injury (WMI) and cerebral palsy (CP).
Methods
This is a retrospective study of newborns admitted between 2011 and 2014. Inclusion criteria were: (1) gestation <29 weeks, (2) birth weight ≤1500 g, (3) referred within 7 days of life, (4) at least two CUS preformed, (5) brain magnetic resonance imaging (MRI) at term age-equivalent. Intraventricular hemorrhage (IVH) grade was identified and FTHR was measured on all CUS. WMI on MRI was evaluated through (1) injury score (Kidokoro 2013) and (2) fractional anisotropy (FA) on the MRI diffusion tensor imaging. CP was estimated using the gross motor function classification system (GMFCS).
Results
One hundred neonates met the inclusion criteria: 37 with no IVH, 36 with IVH grade 1–2, and 27 with IVH grade 3–4. The FTHR cut-point of 0.51 had the highest sensitivity and specificity for moderate-to-severe WMI. In the IVH grade 3–4 group, the elevated FTHR correlated with lower FA and higher GMFCS.
Conclusions
FTHR is a useful quantitative biomarker of ventriculomegaly in preterm newborns. It may help standardize ventricular measurement and direct intervention.
Impact
The fronto-temporal horn ratio has the potential to become a standardized tool that can provide an actionable measure to direct intervention for post-hemorrhagic ventricular dilation.
This current study will provide the basis of a future clinical trial to optimize intervention timing to decrease the risk of white matter injury in this vulnerable population.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33504959</pmid><doi>10.1038/s41390-020-01337-x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric research, 2021-05, Vol.89 (7), p.1715-1723 |
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| language | eng |
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| source | Springer Nature |
| subjects | Biomarkers Clinical Research Article Humans Hydrocephalus - diagnostic imaging Hydrocephalus - pathology Infant, Newborn Infant, Premature Magnetic resonance imaging Medicine Medicine & Public Health Pediatric Surgery Pediatrics Retrospective Studies Temporal Lobe - diagnostic imaging Temporal Lobe - pathology Ultrasonic imaging Ultrasonography |
| title | The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker |
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