Luteolin, inflammation and cancer: Special emphasis on gut microbiota

Luteolin belongs to the family of flavonoids, which have anti‐inflammatory functions, potentially useful in a clinical context, particularly for patients suffering from cancer, neuropsychiatric disorders, inflammatory bowel conditions. This peculiarity has been used for centuries in traditional Chin...

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Bibliographic Details
Published in:BioFactors (Oxford) 2021-03, Vol.47 (2), p.181-189
Main Authors: Franza, Laura, Carusi, Valentina, Nucera, Eleonora, Pandolfi, Franco
Format: Article
Language:English
Subjects:
flavonoids
immunology
inflammation
luteolin
microbiota
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Summary:Luteolin belongs to the family of flavonoids, which have anti‐inflammatory functions, potentially useful in a clinical context, particularly for patients suffering from cancer, neuropsychiatric disorders, inflammatory bowel conditions. This peculiarity has been used for centuries in traditional Chinese medicine, for many different diseases. Its anti‐inflammatory effects might be particularly relevant in cancer, with some studies reporting anti‐angiogenesis, anti‐metastatic, and apoptotic effects on cancer cells by luteolin and other flavonoids. In this article, we analyze the anti‐inflammatory role of luteolin, discussing the pathways it may act on. We will then discuss the possible role of microbiota in inflammatory modulation by luteolin. Finally, the possible therapeutic applications of luteolin's anti‐inflammatory properties will be analyzed, with a particular focus on cancer.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.1710