Forkhead Transcription Factors in Health and Disease

Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to p...

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Bibliographic Details
Published in:Trends in genetics 2021-05, Vol.37 (5), p.460-475
Main Authors: Herman, Laetitia, Todeschini, Anne-Laure, Veitia, Reiner A.
Format: Article
Language:English
Subjects:
cancer
forkhead box factors
Forkhead transcription factors
human diseasen
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Summary:Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in the adult. Genetic alterations or misregulation of FOX genes underlie human genetic diseases, cancer, and/or aging. In this review, we provide an updated overview of the main characteristics of the members of this family, in terms of breadth of expression, protein domain composition, evolution, and function. Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors involved in critical functions during development and in the adult.FOX proteins display some degree of functional redundancy as well as specific roles.Alterations of FOX genes are responsible for human genetic diseases, cancer, and aging.
ISSN:0168-9525
DOI:10.1016/j.tig.2020.11.003