Subclinical effects of adapalene‐benzoyl peroxide: a prospective in vivo imaging study on acne micromorphology and transfollicular delivery

Background Adapalene–benzoyl peroxide (A‐BPO) is a first‐line topical treatment for acne vulgaris. In vivo reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) detect micromorphological changes over time and visualize transfollicular delivery. Objectives To visualize temporal...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2021-06, Vol.35 (6), p.1377-1385
Main Authors: Fuchs, C.S.K., Ortner, V.K., Hansen, F.S., Philipsen, P.A., Haedersdal, M.
Format: Article
Language:English
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Summary:Background Adapalene–benzoyl peroxide (A‐BPO) is a first‐line topical treatment for acne vulgaris. In vivo reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) detect micromorphological changes over time and visualize transfollicular delivery. Objectives To visualize temporal, subclinical effects of A‐BPO on acne micromorphology using RCM and OCT, and evaluate their impact on transfollicular delivery of microparticulate carrier systems. Methods Fifteen patients with mild to moderate acne received a 6‐week course of A‐BPO. Micromorphological changes were evaluated at time 0, 3 and 6 weeks with RCM (n = 1190 images) and OCT (n = 210 scans). Transfollicular delivery of microparticles was assessed at baseline and week 6. Results In vivo imaging visualized steady normalization of skin micromorphology in response to A‐BPO over 6 weeks, including decreased hyperkeratinization of follicular borders (RCM median decrease −71.2%, P 
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.17140