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Randomised study of intra-oral kinetics of fluoride-containing toothpastes

This randomised, controlled, analyst blind, crossover study aimed to evaluate and compare salivary fluoride and calcium ion concentration over 60 min following brushing with an assigned treatment and following an orange juice (OJ) or deionised (DI) water rinse 60 min post-brushing. Study treatments,...

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Published in:Journal of dentistry 2021-03, Vol.106, p.103587-103587, Article 103587
Main Authors: Parkinson, Charles R., Burnett, Gary R., Thomas, Gavin V., Davies, Luke, Payne, David
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Burnett, Gary R.
Thomas, Gavin V.
Davies, Luke
Payne, David
description This randomised, controlled, analyst blind, crossover study aimed to evaluate and compare salivary fluoride and calcium ion concentration over 60 min following brushing with an assigned treatment and following an orange juice (OJ) or deionised (DI) water rinse 60 min post-brushing. Study treatments, both containing 1150 ppm fluoride as NaF and 5% w/w KNO3, were the Test (including 1.2 % w/w cocamidopropyl betaine) and Comparator (including tetrasodium pyrophosphate and sodium lauryl sulphate) toothpastes. Twenty nine participants were randomised to treatment. A sharp increase in salivary fluoride ion concentration immediately post-brushing with either toothpaste decreased over time. Fluoride concentration following Test toothpaste use was numerically higher than the Comparator at all timepoints, with a significant difference from 10 min post-brushing (p < .05). Following the 60 min rinse, there were no significant differences between the Test or Comparator + OJ groups in salivary fluoride concentration but the Test + DI water group was significantly lower than Test (p < .001) or Comparator (p < .001) + OJ groups. A reduction in salivary calcium ion concentration was seen immediately post-brushing and after the OJ rinse with both toothpastes. Significant differences were observed in favour of the Test toothpaste at all timepoints (p < .05) and for Test and Comparator + OJ group (p < .001) compared with Test + DI water rinse. Both treatments were generally well-tolerated. This study demonstrated that toothpaste formulations with identical declared fluoride concentrations and the same fluoride source give rise to differing intraoral fluoride concentrations over time, which are potentially related to different formulation excipient effects. By understanding the interaction of toothpaste formulation excipients in the oral environment, formulations can be developed that maximise retention of fluoride in the oral environment.
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Significant differences were observed in favour of the Test toothpaste at all timepoints (p &lt; .05) and for Test and Comparator + OJ group (p &lt; .001) compared with Test + DI water rinse. Both treatments were generally well-tolerated. This study demonstrated that toothpaste formulations with identical declared fluoride concentrations and the same fluoride source give rise to differing intraoral fluoride concentrations over time, which are potentially related to different formulation excipient effects. 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ispartof Journal of dentistry, 2021-03, Vol.106, p.103587-103587, Article 103587
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source ScienceDirect Freedom Collection 2022-2024
subjects Betaine
Brushing
Calcium
Calcium fluoride
Calcium ions
Cross-Over Studies
Dental erosion
Dentifrices
Dentistry
Enamel
Excipients
Fluoridation
Fluoride treatments
Fluorides
Fruit juices
Humans
Hypotheses
Ion concentration
Kinetics
Oranges
Sodium dodecyl sulfate
Sodium Fluoride
Sodium lauryl sulfate
Sodium pyrophosphate
Surfactants
Toothbrushing
Toothpaste
Toothpastes
title Randomised study of intra-oral kinetics of fluoride-containing toothpastes
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