Association of Chronic Kidney Disease With In-Hospital Outcomes of Endovascular Stroke Interventions

Data on the differential impact of chronic kidney disease (CKD) on the outcomes of endovascular stroke interventions (ESI) for acute ischemic stroke (AIS) are limited. Adult patients who underwent ESI for AIS between October 1st, 2015 and September 30th, 2019, were identified in a national multicent...

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Published in:Cardiovascular revascularization medicine 2022-01, Vol.34, p.121-125
Main Authors: Osman, Mohammed, Sulaiman, Samian, Alqahtani, Fahad, Harris, Alyssa H., Hohmann, Samuel F., Alkhouli, Mohamad
Format: Article
Language:English
Subjects:
Adult
Brain Ischemia
Chronic kidney disease
Endovascular Procedures - adverse effects
Endovascular stroke interventions
Hospital Mortality
Hospitals
Humans
Ischemic Stroke
Mechanical thrombectomy
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - therapy
Retrospective Studies
Stroke - complications
Stroke - diagnosis
Stroke - therapy
Thrombectomy
Treatment Outcome
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Summary:Data on the differential impact of chronic kidney disease (CKD) on the outcomes of endovascular stroke interventions (ESI) for acute ischemic stroke (AIS) are limited. Adult patients who underwent ESI for AIS between October 1st, 2015 and September 30th, 2019, were identified in a national multicenter database. The primary endpoints were in-hospital mortality and poor functional outcomes. Secondary endpoints included intracranial hemorrhage, mechanical ventilation, pneumonia, myocardial infarction, blood transfusion, length of stay, and cost. A multilevel mixed-effects regression model was used to derive adjusted outcomes. A total of 22,193 AIS patients who underwent ESI at 99 centers were included. Among those, 18,881 (85%) had no CKD, and 3312 (15%) had CKD. Patients with CKD were older and had a higher prevalence of key comorbidities. After multivariable risk adjustment, patients with CKD had significantly higher in-hospital mortality (Odds Ratio [OR] 1.55 [95% Confidence Interval] [CI] 1.40–1.73, p 
ISSN:1553-8389
1878-0938
DOI:10.1016/j.carrev.2021.01.021