Effect of general anesthesia on postoperative melatonin secretion in 4-to 6-year-old children with snoring

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2021-01, Vol.41 (1), p.128-134
• Main Authors: Qiu, Qianqi, Song, Xingrong, Sun, Changzhi, Tan, Yonghong, Xu, Yingyi, Huang, Guiliang, Zhang, Na, Li, Zhengke, Wei, Wei
• Format: Article
• Language: Chinese
• Subjects: Anesthesia, General - adverse effects; Bodily Secretions; Child; Child, Preschool; Circadian Rhythm; Humans; Melatonin; Snoring
• ISSN: 1673-4254
• DOI: 10.12122/j.issn.1673-4254.2021.01.19

To evaluate the effect of general anesthesia on postoperative melatonin secretion in 4-to 6-year-old children with snoring. Twenty children with snoring aged 4-6 years of either gender (ASA grade Ⅰ and Ⅱ) were selected for adenoidectomy.Before, during and 3 days after the operation, salivary melatonin levels of the children were measured at 11 selected time points (T1-T11).The illumination intensity and body temperature of the children were recorded at each time point of measurement.The sleep time of the children in 3 days after the operation was recorded, and postoperative pain scores (FLACC) and Riker and Rehabilitation Quality Rating Scale-15(QoR-15) scores were assessed.Sleep Apnea Life Quality Evaluation Questionnaire (OSA-18) was used to evaluate postoperative recovery of the children at 28 days after the operation.The incidence of major adverse events of the children during hospitalization was recorded. No significant difference was found in baseline salivary melatonin level among the 20 children befor