Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

• Published in: Experimental dermatology 2021-05, Vol.30 (5), p.717-722
• Main Authors: Nieto‐Benito, Lula María, Ciudad‐Blanco, Cristina, Sanmartin‐Jimenez, Onofre, Garces, Joan R., Rodríguez‐Prieto, Manuel A., Vilarrasa, Eva, Eusebio‐Murillo, Esther, Miñano‐Medrano, Román, Escutia‐Muñoz, Begoña, Gonzalez‐Sixto, Beatriz, Artola‐Igarza, Juan L., Alfaro Rubio, Alberto, Redondo, Pedro, Delgado‐Jiménez, Yolanda, Sánchez‐Schmidt, Julia M., Allende‐Markixana, Irati, Alonso‐Pacheco, María L., García‐Bracamonte, Beatriz, Cueva Dobao, Pablo, Navarro‐Tejedor, Raquel, Suarez‐Fernández, Ricardo, Carnero‐González, Lucia, Vázquez‐Veiga, Hugo, Barchino‐Ortiz, Lucia, Ruiz‐Salas, Verónica, Sánchez‐Sambucety, Pedro, López‐Estebaranz, José L., Botella‐Estrada, Rafael, Feal‐Cortizas, Carlos, Martorell Calatayud, Antonio, Gil, Pilar, Morales‐Gordillo, Victoriano, Toll‐Abelló, Agustí, Ocerin‐Guerra, Izascun, Mayor‐Arenal, Matías, Garcia‐Donoso, Carmen, Cano‐Martinez, Natividad, Sainz‐Gaspar, Laura, Descalzo, Miguel A., Garcia‐Doval, Ignacio
• Format: Article
• Language: English
• Subjects: Cohort analysis; Demography; Dermatofibrosarcoma - pathology; Dermatofibrosarcoma - surgery; Dermatofibrosarcoma protuberans; Dermatologic Surgical Procedures - methods; DFSP; Epidemiology; frozen mms; Humans; Literature reviews; local; Micrography; mohs surgery; Mohs Surgery - methods; Neoplasm Invasiveness; neoplasm recurrence; Paraffin; paraffin mms; Prospective Studies; Registries; Risk Factors; skin neoplasms; Skin Neoplasms - pathology; Skin Neoplasms - surgery; Surgery; Tumors
• ISSN: 0906-6705; 1600-0625
• DOI: 10.1111/exd.14291

Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined. In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence. Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities. Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person‐years (95% IC = 0.36–2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence. Median follow‐up time was 28.6 months with 414 patient‐years of follow‐up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.