Is the prediction of one or two ipsilateral positive lymph nodes by computerized tomography and ultrasound reliable enough to restrict therapeutic neck dissection in oral squamous cell carcinoma (OSCC) patients?

• Published in: Journal of cancer research and clinical oncology 2021-08, Vol.147 (8), p.2421-2433
• Main Authors: Sproll, Karl Christoph, Leydag, Sabina, Holtmann, Henrik, Schorn, Lara K., Aissa, Joel, Kröpil, Patric, Kaisers, Wolfgang, Tóth, Csaba, Handschel, Jörg, Lommen, Julian
• Format: Article
• Language: English
• Subjects: Cancer Research; Computed tomography; Head and neck; Hematology; Internal Medicine; Lesions; Lymph nodes; Medicine; Medicine & Public Health; Metastases; Metastasis; Oncology; Oral cancer; Oral squamous cell carcinoma; Original Article – Clinical Oncology; Patients; Squamous cell carcinoma; Surgery; Tomography; Ultrasonic imaging; Ultrasound
• ISSN: 0171-5216; 1432-1335
• DOI: 10.1007/s00432-021-03523-8

Introduction Proper management of the clinically involved neck in OSCC patients continues to be a matter of debate. Our aim was to analyze the accuracy of computerized tomography (CT) and ultrasound (US) in anticipating the exact location of lymph node (LN) metastases of OSCC patients across the AAO-HNS (American Academy of Otolaryngology—Head and Neck Surgery) levels ipsi- and contralaterally. Furthermore, we wanted to assess the suitability of therapeutic selective neck dissection (SND) in patients with one or two ipsilateral positive nodes upon clinical staging (cN1/cN2a and cN2b(2/x) patients). Methods We prospectively analyzed the LN status of patients with primary OSCC using CT and US from 2007 to 2013. LNs were individually assigned to a map containing the AAO-HNS levels; patients bearing a single or just two ipsilateral positive nodes (designated cN1/cN2a or cN2b(2/x) patients either by CT (CT group) or US alone (US group) or in a group combining findings of CT and US (CTUS group)) received an ipsi-ND (I–V) and a contra-ND (I–IV). 78% of the LNs were sent individually for routine histopathological examination; the remaining were dissected and analyzed per neck level. Results Upon the analysis of 1.670 LNs of 57 patients, the exact location of pathology proven LN metastases in cN1 patients was more precisely predicted by US compared to CT with confirmed findings only in levels IA, IB und IIA. Clearly decreasing the number of missed lesions, the findings in the CTUS group nearly kept the spatial reliability of the US group. The same analysis for patients with exactly two supposed ipsilateral lesions (cN2b(2/x)) yielded confirmed metastases from levels I to V for both methods individually and in combination and, therefore, render SND insufficient for these cases. Conclusion Our findings stress the importance of conducting both, CT and US, in patients with primary OSCC. Only the combination of their findings warrants the application of therapeutic SND in patients with a single ipsilateral LN metastasis (cN1/cN2a patients) but not in patients with more than one lesion upon clinical staging (≥ cN2b).