The role of FOXP3 rs3761548 and rs2294021 polymorphisms in pediatrics acute lymphoblastic leukemia: association with risk and response to therapy

FOXP3 X-linked gene has crucial roles in the development and function of regulatory T cells. We investigated the association of FOXP3 rs3761548, rs3761549 and rs2294021 single nucleotide polymorphisms (SNPs) with acute lymphoblastic leukemia (ALL) susceptibility and response to therapy. Genotyping w...

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Bibliographic Details
Published in:Molecular biology reports 2021-02, Vol.48 (2), p.1139-1150
Main Authors: Ghasemi, Zahra, Kalantar, Kurosh, Amirghofran, Zahra
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adolescent
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Child
Child, Preschool
Disease-Free Survival
Female
Forkhead Transcription Factors - genetics
Foxp3 protein
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Genotyping
Haplotypes
Haplotypes - genetics
Histology
Humans
Immunoregulation
Leukemia
Life Sciences
Lymphatic leukemia
Lymphocytes T
Male
Morphology
Original Article
Patients
Pediatrics
Polymorphism, Single Nucleotide - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Prognosis
Risk Factors
Single-nucleotide polymorphism
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Summary:FOXP3 X-linked gene has crucial roles in the development and function of regulatory T cells. We investigated the association of FOXP3 rs3761548, rs3761549 and rs2294021 single nucleotide polymorphisms (SNPs) with acute lymphoblastic leukemia (ALL) susceptibility and response to therapy. Genotyping was performed in 247 patients and 210 healthy subjects. We observed a higher frequency of rs3761548 A carriers and rs2294021 C carriers ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-06154-x