Hyperglycemia-Induced Cardiac Damage Is Alleviated by Heat-Inactivated Lactobacillus reuteri GMNL-263 via Activation of the IGF1R Survival Pathway

Diabetes-induced cardiomyocyte apoptosis is one of the major causes of mortality in patients with diabetes. Numerous studies have indicated the beneficial effects of Lactobacillus reuteri GMNL-263. However, the protective effect of Lactobacillus reuteri GMNL-263 in cardiac damage associated with dia...

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Published in:Probiotics and antimicrobial proteins 2021-08, Vol.13 (4), p.1044-1053
Main Authors: Koay, Ker-Ping, Tsai, Bruce Chi-Kang, Kuo, Chia-Hua, Kuo, Wei-Wen, Luk, Hsiang-Ning, Day, Cecilia Hsuan, Chen, Ray-Jade, Chen, Michael Yu-Chih, Padma, V. Vijaya, Huang, Chih-Yang
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Applied Microbiology
Cardiomyocytes
Cardiotonic Agents
Cell survival
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental
Heart
Hot Temperature
Hyperglycemia
Hyperglycemia - complications
Lactobacillus reuteri
Limosilactobacillus reuteri
Male
Microbiology
Mitochondria
Myocytes, Cardiac
Nutrition
Oral administration
Patients
Protein Science
Rats
Rats, Wistar
Receptor, IGF Type 1
Rodents
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Summary:Diabetes-induced cardiomyocyte apoptosis is one of the major causes of mortality in patients with diabetes. Numerous studies have indicated the beneficial effects of Lactobacillus reuteri GMNL-263. However, the protective effect of Lactobacillus reuteri GMNL-263 in cardiac damage associated with diabetes remains poorly understood. In this study, we aimed to investigate the protective effect of Lactobacillus reuteri GMNL-263 on cardiomyocytes in diabetic rats. Five-week-old male Wistar rats were categorized into normal control group, diabetes group (55 mg/kgw STZ-induced diabetes via intraperitoneal injection), and diabetic animals treated with Lactobacillus reuteri GMNL-263 (10 9  CFU/rat/day, oral administration for 4 weeks). The results were presented that oral administration of a high dose of Lactobacillus reuteri GMNL-263 in diabetic rats activated IGF1R cell survival pathways to decrease the Fas-dependent and mitochondrial-dependent apoptotic pathways induced by hyperglycemia. We found that GMNL-263 significantly attenuated cell apoptosis via the IGF1R survival pathway in diabetic rats. The findings of this study suggest that GMNL-263 treatment maybe an effective therapeutic approach for the prevention of cardiac apoptosis in patients with diabetes. Graphical abstract
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-021-09745-z