Sarcomatoid larynx carcinoma differential clinical evolution, on field statistical considerations

Spindle cell larynx carcinoma (SpCC) represents around 3% of laryngeal cancers. It is originated by a single cancer stem cell undergoing epithelial to mesenchymal transition. This explains the aggressiveness, the peculiar resistance to conventional therapy and the frequent relapses. We focused on th...

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Bibliographic Details
Published in:American journal of otolaryngology 2021-05, Vol.42 (3), p.102934-102934, Article 102934
Main Authors: Ricciardiello, Filippo, Bocchetti, Marco, Pellini, Raul, Palladino, Remo, Caraglia, Michele, Boscaino, Amedeo, Petruzzi, Gerardo, Romano, Francesco Jacopo, Chiurazzi, Bruno, Addeo, Raffaele, Mazzone, Salvatore, Mesolella, Massimo, Oliva, Flavia, Iorio, Brigida
Format: Article
Language:English
Subjects:
Cancer
Disease
Laryngeal cancer
Larynx
Mesenchyme
Mortality
Otolaryngology
Patients
Sarcoma
Spidle cell carcinoma
Squamous cell carcinoma
Statistical analysis
Stem cells
Subgroups
Survival
Survival analysis
Tumors
Variables
Citations: Items that this one cites
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Summary:Spindle cell larynx carcinoma (SpCC) represents around 3% of laryngeal cancers. It is originated by a single cancer stem cell undergoing epithelial to mesenchymal transition. This explains the aggressiveness, the peculiar resistance to conventional therapy and the frequent relapses. We focused on this particular cancer subset characteristics in patients, in early and advanced stages primarily aiming to define and highlight the differences with Laryngeal Squamous Cell Carcinoma (LSCC) focusing on clinical features, treatments, follow-up and survival in a patient's cohort composed by comparable cases from two subgroups.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2021.102934