Transfusion‐associated circulatory overload and high blood pressure: A multicentre retrospective study in Japan

Background Transfusion‐associated circulatory overload (TACO) is an adverse reaction associated with a high risk of mortality. The actual incidence of TACO and hypertension associated with transfusion in Japan is unknown. Methods A multicentre retrospective observational study was conducted across 2...

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Bibliographic Details
Published in:Vox sanguinis 2021-08, Vol.116 (7), p.785-792
Main Authors: Tanaka, Asashi, Yokohama, Akihiko, Fujiwara, Shin‐ichiro, Fujii, Yasuhiko, Kaneko, Makoto, Ueda, Yasunori, Abe, Takashi, Kato, Yoko, Hasegawa, Yuichi, Ikeda, Kazuhiko, Fujino, Keizo, Matsumoto, Mayumi, Makino, Shigeyoshi, Kino, Shuichi, Takeshita, Akihiro, Muroi, Kazuo
Format: Article
Language:English
Subjects:
Blood pressure
BNP
Body temperature
Electronic health records
Electronic medical records
haemovigilance
Heart rate
Hypertension
Overloading
Oxygen content
Patients
Physicians
Risk analysis
Risk factors
Surveillance
Surveillance systems
TACO
Transfusion
vital signs
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Summary:Background Transfusion‐associated circulatory overload (TACO) is an adverse reaction associated with a high risk of mortality. The actual incidence of TACO and hypertension associated with transfusion in Japan is unknown. Methods A multicentre retrospective observational study was conducted across 23 institutions during the 1‐year period of 2016. Patients were included if they developed TACO or their blood pressure (either systolic or diastolic) increased by at least 30 mmHg during the transfusion. TACO was confirmed by the primary physicians and transfusion medicine teams and recorded in the data on passive surveillance, and additional data were extracted from electronic medical records. Results In our patient cohort of 31 384 patients who underwent transfusion, the incidence of TACO and hypertension was 0·03% and 0·2%, respectively. However, 43% of the participating institutions didn't report any cases. When comparing risk factors between the TACO and hypertension groups, there were significant differences in comorbidities, such as abnormal findings on chest x‐ray. Significant differences between the two groups were observed post‐transfusion pulse rate, body temperature and oxygen saturation (P 
ISSN:0042-9007
1423-0410
DOI:10.1111/vox.13063