Gardnerella vaginalis and Trichomonas vaginalis infections as risk factors for persistence and progression of low-grade precancerous cervical lesions in HIV-1 positive women

• Published in: Pathology, research and practice research and practice, 2021-03, Vol.219, p.153349-153349, Article 153349
• Main Authors: Raffone, Antonio, Travaglino, Antonio, Angelino, Antonio, Esposito, Rosanna, Orlandi, Giuliana, Toscano, Paolo, Mollo, Antonio, Insabato, Luigi, Sansone, Matilde, Zullo, Fulvio
• Format: Article
• Language: English
• Subjects: AIDS; Cancer; Cervix; CIN; Immunodeficiency; Neoplasia; SIL; Tumor
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2021.153349

Gardnerella vaginalis (GV) and Trichomonas vaginalis (TV) infections have been proposed as risk factors for persistence and/or progression of low-grade cervical precancerous lesions (CIN1/L-SIL). In patients with Human Immunodeficiency Virus (HIV), who have an increased baseline risk of CIN1/L-SIL progression, the role of GV and TV is undefined. We aimed to investigate the prognostic impact of GV and TV infections on CIN1/L-SIL in HIV-positive women. HIV-1-positive women with L-SIL were retrospectively included. The risk of persistence or progression in the case of any infection (primary outcome), only GV (GV+), only TV (TV+), or GV and TV coinfection (secondary outcomes) was calculated compared to women with no GV or TV infections (NI), by using relative risk (RR) and multivariate logistic regression, with a significant p-value>0.05;. One hundred and ninety-two patients were included (18.2 %GV+, 15.6 %TV+, 5.2 % coinfection, 60.9 %NI); 58 CIN1/L-SIL showed persistence and 46 progression. RR for persistence/progression of CIN1/L-SIL in the case of any infection was 1.56 (1.21−2.01; p = 0.0006) compared to NI. RR for persistence alone was 1.91 (1.25−2.09; p = 0.0026) in GV+, 1.2 (0.63−2.3; p = 0.5736) in TV+, and 2.06 (1.09−3.9; p = 0.0254) in coinfection. RR for progression alone was 1.94 (1.06–3.4; p = 0.0311) in GV+, 2.14 (1.25−3.67; p = 0.0058) in TV+, and 2.73 (1.39−5.37; p = 0.0036) in coinfection. On multivariate analysis, the presence of any infection was significantly associated with persistence/progression (p = 0.002), GV + with persistence (p = 0.019) and TV + with progression (p = 0.016). In conclusion, GV infection is a risk factor for persistence of CIN1/L-SIL in HIV-positive women, while TV infection is a risk factor for progression. Women with these infections may require a closer and more careful follow-up of CIN1/L-SIL.