Oral bisphosphonates for osteoporosis in adult males with intellectual disabilities

Introduction Oral bisphosphonates are first‐line agents for treating osteoporosis in men, but there are no studies regarding efficacy of oral bisphosphonates for treatment of osteoporosis in ambulatory male adults with intellectual disability. Methods Nine adult males with intellectual disability an...

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Bibliographic Details
Published in:Journal of applied research in intellectual disabilities 2021-05, Vol.34 (3), p.921-925
Main Authors: May, Philip B., Parker, Frank
Format: Article
Language:English
Subjects:
Adults
At Risk Persons
Bisphosphonates
Drug Therapy
Fractures
Human Body
Intellectual disabilities
Intellectual Disability
Males
Osteoporosis
Physiology
Program Effectiveness
vitamin D
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Summary:Introduction Oral bisphosphonates are first‐line agents for treating osteoporosis in men, but there are no studies regarding efficacy of oral bisphosphonates for treatment of osteoporosis in ambulatory male adults with intellectual disability. Methods Nine adult males with intellectual disability and increased fracture risk had been treated with weekly or monthly oral bisphosphonates, vitamin D and calcium for 1–3 years. Post‐treatment bone mineral density (BMD), serum 25(OH)D, parathyroid hormone and C‐telopeptide of type I collagen were then determined for the first time. Results Weekly or monthly oral bisphosphonates were well tolerated and led to significant increases in BMD in all 9 individuals. Serum 25(OH)D level enhanced the “pecent increase of BMD” that occurred in response to bisphosphonate treatment (p 
ISSN:1360-2322
1468-3148
DOI:10.1111/jar.12862