Understanding the role of cultural factors in the risk of mild cognitive impairment in diverse populations

The literature has documented many of the challenges investigators face enrolling diverse populations in dementia research and clinical trials (Alzheimer's Association, 2016; Gilmore-Bykovskyi et al., 2019); however, the impact of this underrepresentation on knowledge of disease mechanisms, dru...

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Bibliographic Details
Published in:International psychogeriatrics 2021-01, Vol.33 (1), p.11-13
Main Authors: Gentry, Melanie T., Rummans, Teresa A., Lucas, John A.
Format: Article
Language:English
Subjects:
Acculturation
African Americans
Alzheimer's disease
Bilingualism
Biomarkers
Clinical research
Clinical trials
Cognitive ability
Cognitive impairment
Commentary
Cultural factors
Dementia
Discrimination
Education
Educational attainment
Efficacy
Ethnicity
Hispanic Americans
Latin American cultural groups
Literacy
Mexican Americans
Minority & ethnic groups
Neuropsychology
Noncitizens
Protective factors
Race
Social support
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Summary:The literature has documented many of the challenges investigators face enrolling diverse populations in dementia research and clinical trials (Alzheimer's Association, 2016; Gilmore-Bykovskyi et al., 2019); however, the impact of this underrepresentation on knowledge of disease mechanisms, drug efficacy, and safety warrants continued and concerted efforts in this regard. The authors highlight the ways in which the results are consistent with other findings that Mexican American individuals have a similar risk profile to whites in the United States but that other Latino groups, particularly Caribbean Latinos, have a higher risk of MCI than whites. The authors suggest possible protective factors for Mexican American individuals including different levels of discrimination, acculturation, social support, or genetic factors.
ISSN:1041-6102
1741-203X
DOI:10.1017/S1041610220000435