Xerostomia and hyposalivation in patients with obstructive sleep apnoea

• Published in: Clinical otolaryngology 2021-07, Vol.46 (4), p.782-787
• Main Authors: Makeeva, Irina Michajlovna, Budina, Tatiana Vasilievna, Turkina, Anna Yurjevna, Poluektov, Mikhail Gurevich, Kondratiev, Sergey Alexeevitch, Arakelyan, Marianna Georgievna, Signore, Antonio, Amaroli, Andrea
• Format: Article
• Language: English
• Subjects: Acidity; Adult; Aged; Apnea; Evaluation; Female; flow rate; Flow velocity; Humans; Hydrogen-Ion Concentration; hyposalivation; Male; Middle Aged; Mouth; pH effects; Polysomnography; Saliva; Saliva - chemistry; Salivation; Severity of Illness Index; Sleep; Sleep apnea; Sleep Apnea, Obstructive - complications; Sleep disorders; Statistical analysis; Variance analysis; Xerostomia; Xerostomia - etiology
• ISSN: 1749-4478; 1749-4486
• DOI: 10.1111/coa.13735

Objective (a) To report the xerostomia prevalence and severity in patients with obstructive sleep apnoea (OSA). (b) To assess the saliva pH in patients with OSA. Design Simultaneous cohort observational clinical study. Setting In Sleep Medicine Centre at Lomonosov Moscow State University from March to June 2019. Participants The study was conducted on 30 patients with OSA aged from 35 to 65 years. Main outcomes measures The diagnosis of sleep apnoea was made after standard polysomnography using the Domino programme. The severity of OSA was indicated using the Apnoea‐Hypopnea Index. Xerostomia was evaluated using Fox's test. Hyposalivation was evaluated by measurement of salivary flow rate. Determination of the saliva pH was carried out with a pH metre. Statistical analysis was performed by one‐way ANOVA and Tukey‐Kramer multi‐comparison test. Results Twenty‐two out of 30 (73.3%) patients were diagnosed with "dry mouth". Hyposalivation was observed in 6 out of 30 (20%). Dry mouth on awakening was observed in 60.0%, 72.7% and 88.9% of patients with mild, moderate and severe OSA, respectively. The average salivary flow rate was 0.28 mL/min, 0.24 mL/min and 0.14 mL/min, respectively. The average pH value in patients with mild, moderate and severe apnoea was 6.40 ± 0.017, 6.15 ± 0.27 and 5.87 ± 0.24, respectively. Conclusions In patient with mild and moderate OSA, the saliva amount and rate are similar (P > .05). With the increase of OSA severity, both these parameters change (P