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Metabolic flexibility during late pregnancy is associated with neonatal adiposity

The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assesse...

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Published in:	Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2021-04, Vol.46 (4), p.404-407
Main Authors:	Tinius, Rachel A, Blankenship, Maire M, Furgal, Karen E, Cade, W. Todd, Duchette, Cathryn, Pearson, Kevin J, Maples, Jill M
Format:	Article
Language:	English
Subjects:	Adipose tissues Adiposity Adult Anthropometry Birth Weight Body fat Body Mass Index déplacement du substrat enceinte Female Flexibility Health aspects Humans Infant, Newborn Infants (Newborn) Insulin Resistance Lipid Metabolism lipid oxidation Lipids Maternal Nutritional Physiological Phenomena Medical research Medicine, Experimental Metabolic regulation Metabolism neonates Newborn babies nouveau-nés oxydation lipidique Physiological aspects Pregnancy pregnant Prenatal influences Prospective Studies substrate shifting
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container_title	Applied physiology, nutrition, and metabolism
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creator	Tinius, Rachel A Blankenship, Maire M Furgal, Karen E Cade, W. Todd Duchette, Cathryn Pearson, Kevin J Maples, Jill M
description	The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = −0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319. Novelty: This is the first study to link maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy to neonatal adiposity at parturition.
doi_str_mv	10.1139/apnm-2020-1005
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Clinical Trail Registration Number: NCT03504319. Novelty: This is the first study to link maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy to neonatal adiposity at parturition.</description><subject>Adipose tissues</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Birth Weight</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>déplacement du substrat</subject><subject>enceinte</subject><subject>Female</subject><subject>Flexibility</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Insulin Resistance</subject><subject>Lipid Metabolism</subject><subject>lipid oxidation</subject><subject>Lipids</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolic regulation</subject><subject>Metabolism</subject><subject>neonates</subject><subject>Newborn babies</subject><subject>nouveau-nés</subject><subject>oxydation lipidique</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>pregnant</subject><subject>Prenatal influences</subject><subject>Prospective Studies</subject><subject>substrate shifting</subject><issn>1715-5312</issn><issn>1715-5320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkt1r1jAUxosobszdeikFQXbTmY8maW6EMfyCiQh6HdL09G0kTWqSqu9_v5TN100GkouEk9_zHM7hqarnGJ1jTOVrvfi5IYigBiPEHlXHWGDWMErQ48Mbk6PqNCXbo5YKiiSXT6sjSlnbck6Oqy-fIOs-OGvq0cFv21tn874e1mj9rnY6Q71E2Hntzb62qdYpBWNLeah_2TzVHoLXWbtaD3YJqWifVU9G7RKc3t4n1bd3b79efmiuPr__eHlx1RiGaW40xh3jUgvRtsB7LqQZsOgACZB4pFQzyYEYYzqQSGIy9IRKjShIg1rUt_SkenPju6z9DIMBn6N2aol21nGvgrbq_o-3k9qFn6rDrOOMFYOzW4MYfqyQspptMuCcLkOtSZG2KytkQvKCvvwH_R7W6Mt4ijCMGOa0E3-pnXagrB9D6Ws2U3XBWScYZRIX6vwBqpwBZmuCh9GW-j3BqzuCCbTLUwpuzTb49KCziSGlCONhGRipLTBqC4zaAqO2wBTBi7srPOB_4lEAfAP4aCIk0NFM_zO9BmGGyuA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Tinius, Rachel A</creator><creator>Blankenship, Maire M</creator><creator>Furgal, Karen E</creator><creator>Cade, W. 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subjects	Adipose tissues Adiposity Adult Anthropometry Birth Weight Body fat Body Mass Index déplacement du substrat enceinte Female Flexibility Health aspects Humans Infant, Newborn Infants (Newborn) Insulin Resistance Lipid Metabolism lipid oxidation Lipids Maternal Nutritional Physiological Phenomena Medical research Medicine, Experimental Metabolic regulation Metabolism neonates Newborn babies nouveau-nés oxydation lipidique Physiological aspects Pregnancy pregnant Prenatal influences Prospective Studies substrate shifting
title	Metabolic flexibility during late pregnancy is associated with neonatal adiposity
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