A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders

Ferulic acid is being screened in preclinical settings to combat various neurological disorders. It is a naturally occurring dietary flavonoid commonly found in grains, fruits, and vegetables such as rice, wheat, oats, tomatoes, sweet corn etc., which exhibits protective effects against a number of...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 2021-05, Vol.46 (5), p.1043-1057
Main Authors: Thapliyal, Surabhi, Singh, Tanveer, Handu, Shailendra, Bisht, Manisha, Kumari, Puja, Arya, Priyanka, Srivastava, Pallavi, Gandham, Ravi
Format: Article
Language:English
Subjects:
Acids
Alzheimer's disease
Antioxidants
Bioavailability
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Cell Biology
Corn
Diet
Drug delivery
Drug delivery systems
Epilepsy
Ferulic acid
Flavonoids
Health services
In vivo methods and tests
Inflammation
Injury prevention
Ischemia
Lipids
Movement disorders
Nanoparticles
Neurochemistry
Neurodegenerative diseases
Neurological diseases
Neurological disorders
Neurology
Neurosciences
Parkinson's disease
Polyphenols
Reperfusion
Review
Sweetcorn
Tomatoes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ferulic acid is being screened in preclinical settings to combat various neurological disorders. It is a naturally occurring dietary flavonoid commonly found in grains, fruits, and vegetables such as rice, wheat, oats, tomatoes, sweet corn etc., which exhibits protective effects against a number of neurological diseases such as epilepsy, depression, ischemia-reperfusion injury, Alzheimer’s disease, and Parkinson’s disease. Ferulic acid prevents and treats different neurological diseases pertaining to its potent anti-oxidative and anti-inflammatory effects, beside modulating unique neuro-signaling pathways. It stays in the bloodstream for longer periods than other dietary polyphenols and antioxidants and easily crosses blood brain barrier. The use of novel drug delivery systems such as solid-lipid nanoparticles (SLNs) or its salt forms (sodium ferulate, ethyl ferulate, and isopentyl ferulate) further enhance its bioavailability and cerebral penetration. Based on reported studies, ferulic acid appears to be a promising molecule for treatment of neurological disorders; however, more preclinical (in vitro and in vivo) mechanism-based studies should be planned and conceived followed by its testing in clinical settings.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-021-03257-6