Development of a dose distribution shifter to fit inside the collimator of a Boron Neutron Capture Therapy irradiation system to treat superficial tumours

• Published in: Physica medica 2021-02, Vol.82, p.17-24
• Main Authors: Hu, N., Tanaka, H., Yoshikawa, S., Miyao, M., Akita, K., Aihara, T., Ono, K.
• Format: Article
• Language: English
• Subjects: BNCT; Bolus; Monte Carlo simulation; Neutron moderator; Thermal neutrons
• ISSN: 1120-1797; 1724-191X
• DOI: 10.1016/j.ejmp.2021.01.003

•BNCT is highly effective for malignant melanoma of the skin.•Dose distribution shifter (DDS) was designed to enhance the dose to the skin.•PHITS Monte Carlo simulation was performed to determine the optimum design.•The DDS resulted in reducing the treatment time by approximately 29%.•The system can be adjusted to suit each individual patient plan. The Kansai BNCT Medical Center has a cyclotron based epithermal neutron source for clinical Boron Neutron Capture Therapy. The system accelerates a proton to an energy of 30 MeV which strikes a beryllium target producing fast neutrons which are moderated down to epithermal neutrons for BNCT use. While clinical studies in the past have shown BNCT to be highly effective for malignant melanoma of the skin, to apply BNCT for superficial lesions using this system it is necessary to shift the thermal neutron distribution so that the maximum dose occurs near the surface. A dose distribution shifter was designed to fit inside the collimator to further moderate the neutrons to increase the surface dose and reduce the dose to the underlying normal tissue. Pure polyethylene was selected, and a Monte Carlo simulation was performed to determine the optimum thickness of the polyethylene slab. Compared with the original neutron beam, the shifter increased the thermal neutron flux at the skin by approximately 4 times. The measured and simulated central axis depth distribution and off axis distribution of the thermal neutron flux were found to be in good agreement. Compared with a 2 cm thick water equivalent bolus, a 26% increase in the thermal neutron flux at the surface was obtained, which would reduce the treatment time by approximately 29%. The DDS is a safe, simple and an effective tool for the treatment of superficial tumours for BNCT if an initially fast neutron beam requires moderation to maximise the thermal neutron flux at the tissue surface.