Decreased cardiovascular death in schizophrenia patients treated with antipsychotics: A Korean national cohort study

Patients with schizophrenia have a reduced life expectancy, but the association between antipsychotic usage and cause of death is uncertain. The authors observed associations of antipsychotic usage with the mortality rate and cause of death in a population-based cohort of the Korean National Health...

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Bibliographic Details
Published in:Schizophrenia research 2021-02, Vol.228, p.417-424
Main Authors: Oh, Jihoon, Nam, Hyewon, Park, Sangmin, Chae, Jeong-Ho, Kim, Tae-Suk
Format: Article
Language:English
Subjects:
Antipsychotics
Cardiovascular diseases
Mortality
National cohort
Schizophrenia
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Summary:Patients with schizophrenia have a reduced life expectancy, but the association between antipsychotic usage and cause of death is uncertain. The authors observed associations of antipsychotic usage with the mortality rate and cause of death in a population-based cohort of the Korean National Health Insurance Service database from 2003 to 2017. A total of 86,923 patients with schizophrenia were categorized by the total duration of antipsychotic prescription after schizophrenia diagnosis into treated (n = 77,139) and untreated (n = 9784) groups. The main outcome was all-cause mortality; causes of death included cardiovascular disease, pulmonary disease, diabetes, cancer, accident, suicide and homicide. The numbers of all-cause deaths and deaths from individual causes were significantly lower in the antipsychotic-treated group than in the untreated group (all cases, p 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2021.01.006